Chapter title |
EG-VEGF Maintenance Over Early Gestation to Develop a Pregnancy-Induced Hypertensive Animal Model
|
---|---|
Chapter number | 25 |
Book title |
Preeclampsia
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7498-6_25 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7497-9, 978-1-4939-7498-6
|
Authors |
Déborah Reynaud, Frédéric Sergent, Roland Abi Nahed, Sophie Brouillet, Mohamed Benharouga, Nadia Alfaidy |
Abstract |
During the last decade, multiple animal models have been developed to mimic hallmarks of pregnancy-induced hypertension (PIH) diseases, which include gestational hypertension, preeclampsia (PE), or eclampsia. Converging in vitro, ex vivo, and clinical studies from our group strongly suggested the potential involvement of the new angiogenic factor EG-VEGF (endocrine gland-derived-VEGF) in the development of PIH. Here, we described the protocol that served to demonstrate that maintenance of EG-VEGF production over 11.5 days post coitus (dpc) in the gravid mice caused the development of PIH. The developed model exhibited most hallmarks of preeclampsia. |
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