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Chapter title |
Use of GATA3 and TWIST1 Immunofluorescence Staining to Assess In Vitro Syncytial Fusion Index
|
---|---|
Chapter number | 13 |
Book title |
Preeclampsia
|
Published in |
Methods in molecular biology, January 2018
|
DOI | 10.1007/978-1-4939-7498-6_13 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7497-9, 978-1-4939-7498-6
|
Authors |
Severine A. Degrelle, Thierry Fournier |
Abstract |
In human placenta, the multinucleated syncytiotrophoblast (ST) allows all the exchanges between the maternal and fetal circulation and is also the site of placental hormonal functions. Absence or disturbances of ST formation are associated with a defect or pathologies of pregnancy such as preeclampsia (PE) and intrauterine growth retardation (IUGR). All along pregnancy, the ST is regenerated by fusion of underlying mononucleated villous cytotrophoblasts (VCT). The protocol described here provides details on how GATA3 or TWIST1 immunostaining and analysis can be used to easily assess the in vitro differentiation of human placental cytotrophoblast. |
Mendeley readers
The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 12 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 3 | 25% |
Student > Master | 2 | 17% |
Student > Bachelor | 1 | 8% |
Lecturer > Senior Lecturer | 1 | 8% |
Student > Ph. D. Student | 1 | 8% |
Other | 0 | 0% |
Unknown | 4 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 4 | 33% |
Nursing and Health Professions | 2 | 17% |
Immunology and Microbiology | 2 | 17% |
Unknown | 4 | 33% |