Chapter title |
In Vitro Induction of Hypoxia/Reoxygenation on Placental Cells: A Suitable Model for Understanding Placental Diseases. - PubMed - NCBI
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Chapter number | 21 |
Book title |
Preeclampsia
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Published in |
Methods in molecular biology, January 2018
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DOI | 10.1007/978-1-4939-7498-6_21 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7497-9, 978-1-4939-7498-6
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Authors |
Lucas Sagrillo-Fagundes, Laetitia Laurent, Josianne Bienvenue-Pariseault, Cathy Vaillancourt, Sagrillo-Fagundes, Lucas, Laurent, Laetitia, Bienvenue-Pariseault, Josianne, Vaillancourt, Cathy |
Abstract |
Lack of blood flow and aberrant levels of oxygenation in placentas are recurrent in pregnancy diseases, such as preeclampsia. These alterations generate situations of hypoxia and hypoxia/reoxygenation (H/R) and consequent oxidative stress, increased cell death, and inflammation in trophoblasts. The models used to understand the effects of hypoxia and H/R on trophoblasts require a rather big structure. This chapter describes the details of a suitable and reasonable approach with hypoxia chambers to expose human placental trophoblasts to variable conditions of oxygenation. |
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