Chapter title |
Hypoxia-mediated metastasis.
|
---|---|
Chapter number | 3 |
Book title |
Tumor Microenvironment and Cellular Stress
|
Published in |
Advances in experimental medicine and biology, November 2013
|
DOI | 10.1007/978-1-4614-5915-6_3 |
Pubmed ID | |
Book ISBNs |
978-1-4614-5914-9, 978-1-4614-5915-6
|
Authors |
Chang J, Erler J, Joan Chang, Janine Erler, Chang, Joan, Erler, Janine |
Abstract |
Metastasis is responsible for more than 90 % of deaths among cancer patient. It is a highly complex process that involves the interplay between cancer cells, the tumor microenvironment, and even noncancerous host cells. Metastasis can be seen as a step-wise process: acquisition of malignant phenotype, invasion into surrounding tissue, intravasation into blood vessels, survival in circulation, extravasation to distant sites, and colonization of new organs. Before the actual metastatic process, the secondary site is also prepared for the arrival of the cancer cells through formation of "premetastatic niches." Hypoxia (low oxygen tension) is commonly found in solid tumors more than a few millimeters cubed and often is associated with a poor prognosis. Hypoxia increases angiogenesis, cancer cell survival, and metastasis. This chapter described how hypoxia regulates each step of the metastatic process and how blocking hypoxia-driven metastasis through targeting hypoxia-inducible factor 1, or downstream effector molecules such as the lysyl oxidase family may represent highly effective preventive strategies against metastasis in cancer patients. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Demographic breakdown
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Researcher | 8 | 19% |
Student > Bachelor | 8 | 19% |
Student > Doctoral Student | 2 | 5% |
Professor > Associate Professor | 2 | 5% |
Other | 1 | 2% |
Unknown | 10 | 23% |
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Energy | 1 | 2% |
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Unknown | 12 | 28% |