Chapter title |
Differentiation, Regulation and Function of Th9 Cells.
|
---|---|
Chapter number | 7 |
Book title |
T Helper Cell Differentiation and Their Function
|
Published in |
Advances in experimental medicine and biology, September 2014
|
DOI | 10.1007/978-94-017-9487-9_7 |
Pubmed ID | |
Book ISBNs |
978-9-40-179486-2, 978-9-40-179487-9
|
Authors |
Jia L, Wu C, Lei Jia, Changyou Wu, Jia, Lei, Wu, Changyou |
Abstract |
Naïve CD4(+) T cells are activated and differentiate to distinct lineages of T helper (Th) cells, which are involved in physiological and pathological processes by obtaining the potential to produce different lineage-specific cytokines that mediate adaptive immunity. In the past decade, our knowledge of Th cells has been significantly expanded with the findings of new lineages. Interleukin (IL)-9 producing T cells are recently identified. In consideration of the ability to preferentially secret IL-9, these cells are termed Th9 cells. Given the multiple function of IL-9, Th9 cells participate in the lesion of many diseases, such as allergic inflammation, tumor, and parasitosis. In this chapter, we will focus on the cytokines, co-stimulatory factors, and transcriptional signaling pathways, which regulate Th9 cells development as well as stability, plasticity, and the multiple roles of Th9 cells in vivo. |
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