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Mouse Genetics

Overview of attention for book
Cover of 'Mouse Genetics'

Table of Contents

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    Book Overview
  2. Altmetric Badge
    Chapter 1 Development of Pronuclear Injection-Based Targeted Transgenesis in Mice Through Cre– loxP Site-Specific Recombination
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    Chapter 2 Generation of Conditional Knockout Mice
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    Chapter 3 Generating Mouse Lines for Lineage Tracing and Knockout Studies
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    Chapter 4 Generation of an Allelic Series of Knock-In Mice Using Recombinase-Mediated Cassette Exchange (RMCE)
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    Chapter 5 Generating Chimeric Mice from Embryonic Stem Cells via Vial Coculturing or Hypertonic Microinjection
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    Chapter 6 Genetic Inducible Fate Mapping in Adult Mice Using Tamoxifen-Dependent Cre Recombinases
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    Chapter 7 Intracytoplasmic Sperm Injection (ICSI)-Mediated Transgenesis in Mice
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    Chapter 8 Generation of Bacterial Artificial Chromosome (BAC) Transgenic Mice
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    Chapter 9 Generation of Genetically Engineered Mice by the piggyBac Transposon System.
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    Chapter 10 Generation and Applications of MADM-Based Mouse Genetic Mosaic System.
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    Chapter 11 Generation of Mouse Lines Conditionally Over-expressing MicroRNA Using the Rosa26-Lox-Stop-Lox System
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    Chapter 12 In Situ Hybridization (Both Radioactive and Nonradioactive) and Spatiotemporal Gene Expression Analysis
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    Chapter 13 Isolation and Handling of Mouse Embryonic Fibroblasts
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    Chapter 14 Generation of Induced Pluripotent Stem Cells from Mouse Adipose Tissue
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    Chapter 15 Pdx1 (GFP/w) Mice for Isolation, Characterization, and Differentiation of Pancreatic Progenitor Cells
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    Chapter 16 Generation of Transgenic Mouse Fluorescent Reporter Lines for Studying Hematopoietic Development
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    Chapter 17 Analyzing gene function in adult long-term hematopoietic stem cells using the interferon inducible mx1-cre mouse system.
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    Chapter 18 Generation of Transgenic Mice by Exploiting Spermatogonial Stem Cells In Vivo
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    Chapter 19 Methods for the Detection of Genome Instability Derived from Replication Stress in Primary Mouse Embryonic Fibroblasts
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    Chapter 20 Transgenic Nude Mice Ubiquitously Expressing Fluorescent Proteins for Color-Coded Imaging of the Tumor Microenvironment
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    Chapter 21 Genetically engineered insertional mutagenesis in mice to model cancer: sleeping beauty.
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    Chapter 22 Generating Double Knockout Mice to Model Genetic Intervention for Diabetic Cardiomyopathy in Humans
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    Chapter 23 Experimental Osteoarthritis Models in Mice
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    Chapter 24 Mouse Models and Methods for Studying Human Disease, Acute Kidney Injury (AKI)
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    Chapter 25 Mouse Models of Acute and Chronic Colitis
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    Chapter 26 Manipulation and Assessment of Gut Microbiome for Metabolic Studies
Attention for Chapter 21: Genetically engineered insertional mutagenesis in mice to model cancer: sleeping beauty.
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Chapter title
Genetically engineered insertional mutagenesis in mice to model cancer: sleeping beauty.
Chapter number 21
Book title
Mouse Genetics
Published in
Methods in molecular biology, July 2014
DOI 10.1007/978-1-4939-1215-5_21
Pubmed ID
Book ISBNs
978-1-4939-1214-8, 978-1-4939-1215-5
Authors

Howell VM, Colvin EK, Viive M. Howell, Emily K. Colvin, Howell, Viive M., Colvin, Emily K.

Abstract

The ability to accurately model human cancer in mice enables in vivo examination of the biological mechanisms related to cancer initiation and progression as well as preclinical testing of new anticancer treatments and potential targets. The emergence of the genetically engineered Sleeping Beauty system of insertional mutagenesis has led to the development of a new generation of genetic mouse models of cancer and identification of novel cancer-causing genes. This chapter reviews the published cancer models of Sleeping Beauty and strategies using available strains to generate several models of cancer.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 2 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 2 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 50%
Student > Master 1 50%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 50%
Unknown 1 50%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2015.
All research outputs
#13,922,082
of 22,768,097 outputs
Outputs from Methods in molecular biology
#3,918
of 13,090 outputs
Outputs of similar age
#114,445
of 228,357 outputs
Outputs of similar age from Methods in molecular biology
#14
of 69 outputs
Altmetric has tracked 22,768,097 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,090 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 228,357 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 79% of its contemporaries.