| Chapter title |
Regulation of Gene and Protein Expression in the Lyme Disease Spirochete
|
|---|---|
| Chapter number | 49 |
| Book title |
Spirochete Biology: The Post Genomic Era
|
| Published in |
Current topics in microbiology and immunology, January 2017
|
| DOI | 10.1007/82_2017_49 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-989637-3, 978-3-31-989638-0
|
| Authors |
Brian Stevenson, Janakiram Seshu |
| Abstract |
The infectious cycle of Borrelia burgdorferi necessitates persistent infection of both vertebrates and ticks, and efficient means of transmission between those two very different types of hosts. The Lyme disease spirochete has evolved mechanisms to sense its location in the infectious cycle, and use that information to control production of the proteins and other factors required for each step. Numerous components of borrelial regulatory pathways have been characterized to date. Their effects are being pieced together, thereby providing glimpses into a complex web of cooperative and antagonistic interactions. In this chapter, we present a broad overview of B. burgdorferi gene and protein regulation during the natural infectious cycle, discussions of culture-based methods for elucidating regulatory mechanisms, and summaries of many of the known regulatory proteins and small molecules. We also highlight areas that are in need of substantially more research. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 24 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 5 | 21% |
| Student > Ph. D. Student | 4 | 17% |
| Student > Bachelor | 2 | 8% |
| Lecturer | 1 | 4% |
| Professor | 1 | 4% |
| Other | 3 | 13% |
| Unknown | 8 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 17% |
| Immunology and Microbiology | 4 | 17% |
| Biochemistry, Genetics and Molecular Biology | 3 | 13% |
| Medicine and Dentistry | 1 | 4% |
| Unknown | 12 | 50% |