| Chapter title |
Anti-viral tetris: modulation of the innate anti-viral immune response by A20.
|
|---|---|
| Chapter number | 4 |
| Book title |
The Multiple Therapeutic Targets of A20
|
| Published in |
Advances in experimental medicine and biology, October 2014
|
| DOI | 10.1007/978-1-4939-0398-6_4 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-0397-9, 978-1-4939-0398-6
|
| Authors |
Arguello M, Paz S, Ferran C, Moll HP, Hiscott J, Arguello, Meztli, Paz, Suzanne, Ferran, Christiane, Moll, Herwig P., Hiscott, John |
| Abstract |
The A20 protein has emerged as an important negative regulator of Toll like receptor (TLR) and retinoic acid-inducible gene 1 (RIG-I)-mediated anti-viral signaling. A20 functions both as a RING-type E3 ubiquitin ligase and as a de-ubiquitinating enzyme. Nuclear factor kappa B (NF-kappaB) and interferon regulatory factor (IRF) pathways are targeted by A20 through mechanisms that appear to be both overlapping and distinct, resulting in the downregulation of interferon alpha/beta (IFNalpha/beta) production. This review specifically details the impact of A20 on the cytosolic RIG-I/MDA5 pathway, a process that is less understood than that of NF-kappaB but is essential for the regulation of the innate immune response to viral infection. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 1 | 33% |
| Lecturer > Senior Lecturer | 1 | 33% |
| Student > Master | 1 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 1 | 33% |
| Immunology and Microbiology | 1 | 33% |
| Unknown | 1 | 33% |