| Chapter title |
Biomolecular Halogen Bonds.
|
|---|---|
| Chapter number | 551 |
| Book title |
Halogen Bonding I
|
| Published in |
Topics in current chemistry, October 2014
|
| DOI | 10.1007/128_2014_551 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-914056-8, 978-3-31-914057-5
|
| Authors |
P Shing Ho, P. Shing Ho, Ho, P. Shing |
| Abstract |
Halogens are atypical elements in biology, but are common as substituents in ligands, including thyroid hormones and inhibitors, which bind specifically to proteins and nucleic acids. The short-range, stabilizing interactions of halogens - now seen as relatively common in biology - conform generally to halogen bonds characterized in small molecule systems and as described by the σ-hole model. The unique properties of biomolecular halogen bonds (BXBs), particularly in their geometric and energetic relationship to classic hydrogen bonds, make them potentially powerful tools for inhibitor design and molecular engineering. This chapter reviews the current research on BXBs, focusing on experimental studies on their structure-energy relationships, how these studies inform the development of computational methods to model BXBs, and considers how BXBs can be applied to the rational design of more effective inhibitors against therapeutic targets and of new biological-based materials. |
X Demographics
Geographical breakdown
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|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
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|---|---|---|
| Student > Ph. D. Student | 7 | 27% |
| Student > Bachelor | 5 | 19% |
| Professor | 4 | 15% |
| Student > Master | 2 | 8% |
| Researcher | 2 | 8% |
| Other | 2 | 8% |
| Unknown | 4 | 15% |
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|---|---|---|
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| Agricultural and Biological Sciences | 1 | 4% |
| Unspecified | 1 | 4% |
| Psychology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 4 | 15% |