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Mendeley readers
| Chapter title |
Testing Experimental Therapies in a Guinea Pig Model for Hemorrhagic Fever
|
|---|---|
| Chapter number | 21 |
| Book title |
Hemorrhagic Fever Viruses
|
| Published in |
Methods in molecular biology, January 2018
|
| DOI | 10.1007/978-1-4939-6981-4_21 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6980-7, 978-1-4939-6981-4
|
| Authors |
Gary Wong, Yuhai Bi, Gary Kobinger, George F. Gao, Xiangguo Qiu |
| Abstract |
Hemorrhagic fever viruses are among the deadliest pathogens known to humans, and often, licensed medical countermeasures are unavailable to prevent or treat infections. Guinea pigs are a commonly used animal for the preclinical development of any experimental candidates, typically to confirm data generated in mice and as a way to validate and support further testing in nonhuman primates. In this chapter, we use Sudan virus (SUDV), a lethal filovirus closely related to Ebola virus, as an example of the steps required for generating a guinea pig-adapted isolate that is used to test a monoclonal antibody-based therapy against viral hemorrhagic fevers. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 43% |
| Student > Bachelor | 2 | 29% |
| Student > Doctoral Student | 1 | 14% |
| Unknown | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 2 | 29% |
| Immunology and Microbiology | 2 | 29% |
| Veterinary Science and Veterinary Medicine | 1 | 14% |
| Agricultural and Biological Sciences | 1 | 14% |
| Unknown | 1 | 14% |