Chapter title |
Gene cloning of BM180, a lacrimal gland enriched basement membrane protein with a role in stimulated secretion.
|
---|---|
Chapter number | 4 |
Book title |
Lacrimal Gland, Tear Film, and Dry Eye Syndromes 2
|
Published in |
Advances in experimental medicine and biology, January 1998
|
DOI | 10.1007/978-1-4615-5359-5_4 |
Pubmed ID | |
Book ISBNs |
978-1-4613-7445-9, 978-1-4615-5359-5
|
Authors |
Asrani, A C, Lumsden, A J, Kumar, R, Laurie, G W, Anil C. Asrani, Angela J. Lumsden, Rajesh Kumar, Gordon W. Laurie, Asrani, Anil C., Lumsden, Angela J., Kumar, Rajesh, Laurie, Gordon W. |
Abstract |
BM180 is a novel basement membrane component with a role in regulated tear secretion by lacrimal acinar cells. BM180 bears some sequence similarity to alpha-gliadin, a plant protein against which antibodies have been reported in patients with Sjögren's syndrome. A precedent for plantlike sequence in the mammalian genome is provided by selectins, which possess a plant lectinlike domain involved in inflammatory cell homing. Cloning the mouse and human BM180 gene will aid molecular investigation of lacrimal acinar cell-BM180 interactions and may lead to a new molecular understanding of mechanisms contributing to dry eye. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 2 | 33% |
Student > Postgraduate | 1 | 17% |
Researcher | 1 | 17% |
Student > Doctoral Student | 1 | 17% |
Student > Master | 1 | 17% |
Other | 0 | 0% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 2 | 33% |
Nursing and Health Professions | 1 | 17% |
Psychology | 1 | 17% |
Immunology and Microbiology | 1 | 17% |
Medicine and Dentistry | 1 | 17% |
Other | 0 | 0% |