| Chapter title |
Mitochondria and aging.
|
|---|---|
| Chapter number | 14 |
| Book title |
Advances in Mitochondrial Medicine
|
| Published in |
Advances in experimental medicine and biology, March 2012
|
| DOI | 10.1007/978-94-007-2869-1_14 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-072868-4, 978-9-40-072869-1
|
| Authors |
Lee HC, Wei YH, Hsin-Chen Lee Ph.D., Yau-Huei Wei, Hsin-Chen Lee |
| Editors |
Roberto Scatena, Patrizia Bottoni, Bruno Giardina |
| Abstract |
Aging is a degenerative process that is associated with progressive accumulation of deleterious changes with time, reduction of physiological function and increase in the chance of disease and death. Studies in several species reveal a wide spectrum of alterations in mitochondria and mitochondrial DNA (mtDNA) with aging, including (1) increased disorganization of mitochondrial structure, (2) decline in mitochondrial oxidative phosphorylation (OXPHOS) function, (3) accumulation of mtDNA mutation, (4) increased mitochondrial production of reactive oxygen species (ROS) and (5) increased extent of oxidative damage to DNA, proteins, and lipids. In this chapter, we outline the common alterations in mitochondria of the aging tissues and recent advances in understanding the role of mitochondrial H(2)O(2) production and mtDNA mutation in the aging process and lifespan determination. In addition, we discuss the effect of caloric restriction on age-associated mitochondrial changes and its role in longevity. Taking these findings together, we suggest that decline in mitochondrial energy metabolism, enhanced mitochondrial oxidative stress, and accumulation of mtDNA mutations are important contributors to human aging. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 10 | 32% |
| Argentina | 3 | 10% |
| Chile | 2 | 6% |
| El Salvador | 1 | 3% |
| Mexico | 1 | 3% |
| Colombia | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Paraguay | 1 | 3% |
| Unknown | 11 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 28 | 90% |
| Practitioners (doctors, other healthcare professionals) | 3 | 10% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Philippines | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 144 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 32 | 22% |
| Student > Ph. D. Student | 24 | 16% |
| Researcher | 16 | 11% |
| Professor > Associate Professor | 10 | 7% |
| Student > Doctoral Student | 10 | 7% |
| Other | 28 | 19% |
| Unknown | 27 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 49 | 33% |
| Biochemistry, Genetics and Molecular Biology | 29 | 20% |
| Medicine and Dentistry | 18 | 12% |
| Neuroscience | 10 | 7% |
| Chemistry | 3 | 2% |
| Other | 6 | 4% |
| Unknown | 32 | 22% |