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Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity

Overview of attention for book
Cover of 'Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 58 Regulatory T Cells: Molecular and Cellular Basis for Immunoregulation
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    Chapter 59 Overview of LAG-3-Expressing, IL-10-Producing Regulatory T Cells
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    Chapter 60 Regulatory Dendritic Cells
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    Chapter 61 CTLA-4, an Essential Immune-Checkpoint for T-Cell Activation
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    Chapter 62 Tim-3, Lag-3, and TIGIT
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    Chapter 63 SOCS1: Regulator of T Cells in Autoimmunity and Cancer
  8. Altmetric Badge
    Chapter 64 Immune Regulation by Ubiquitin Tagging as Checkpoint Code
  9. Altmetric Badge
    Chapter 65 MicroRNA in Immune Regulation
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    Chapter 67 Role of PD-1 in Immunity and Diseases
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    Chapter 68 Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity
  12. Altmetric Badge
    Chapter 69 Erratum to: Role of PD-1 in Immunity and Diseases
Attention for Chapter 68: Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity
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Chapter title
Mining the Complex Family of Protein Tyrosine Phosphatases for Checkpoint Regulators in Immunity
Chapter number 68
Book title
Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity
Published in
Current topics in microbiology and immunology, January 2017
DOI 10.1007/82_2017_68
Pubmed ID
28929190
Book ISBNs
978-3-31-968928-9, 978-3-31-968929-6
Authors

Claudia Penafuerte, Luis Alberto Perez-Quintero, Valerie Vinette, Teri Hatzihristidis, Michel L. Tremblay

Abstract

The family of protein tyrosine phosphatases (PTPs) includes 107 genes in humans that are diverse in their structures and expression profiles. The majority are present in immune cells and play various roles in either inhibiting or promoting the duration and amplitude of signaling cascades. Several PTPs, including TC-PTP (PTPN2) and SHP-1 (PTPN6), have been recognized as being crucial for maintaining proper immune response and self-tolerance, and have gained recognition as true immune system checkpoint modulators. This chapter details the most recent literature on PTPs and immunity by examining their known functions in regulating signaling from either established checkpoint inhibitors or by their intrinsic properties, as modulators of the immune response. Notably, we review PTP regulatory properties in macrophages, antigen-presenting dendritic cells, and T cells. Overall, we present the PTP gene family as a remarkable source of novel checkpoint inhibitors wherein lies a great number of new targets for immunotherapies.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 11 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 2 18%
Researcher 2 18%
Student > Ph. D. Student 2 18%
Student > Bachelor 1 9%
Professor 1 9%
Other 1 9%
Unknown 2 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 36%
Agricultural and Biological Sciences 2 18%
Computer Science 1 9%
Immunology and Microbiology 1 9%
Economics, Econometrics and Finance 1 9%
Other 0 0%
Unknown 2 18%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2019.
All research outputs
#14,955,443
of 23,002,898 outputs
Outputs from Current topics in microbiology and immunology
#419
of 679 outputs
Outputs of similar age
#243,413
of 421,223 outputs
Outputs of similar age from Current topics in microbiology and immunology
#23
of 44 outputs
Altmetric has tracked 23,002,898 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 679 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 421,223 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 44 others from the same source and published within six weeks on either side of this one. This one is in the 40th percentile – i.e., 40% of its contemporaries scored the same or lower than it.

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