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Human Cell Transformation

Overview of attention for book
Cover of 'Human Cell Transformation'

Table of Contents

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    Book Overview
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    Chapter 1 Nuclear Barrier Hypothesis of Aging as Mechanism for Trade-Off Growth to Survival
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    Chapter 2 Establishment of Cell Lines from the Human Middle and Inner Ear Epithelial Cells
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    Chapter 3 Cellular Systems for Studying Human Oral Squamous Cell Carcinomas
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    Chapter 4 Heterotopic Ossification Following Musculoskeletal Trauma: Modeling Stem and Progenitor Cells in Their Microenvironment
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    Chapter 5 Comparative Proteomic Analysis of Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord and Placenta: Implication in the Migration
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    Chapter 6 Novel Human Prostate Epithelial Cell Culture Models for the Study of Carcinogenesis and of Normal Stem Cells and Cancer Stem Cells
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    Chapter 7 Prostate tumor cell plasticity: a consequence of the microenvironment.
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    Chapter 8 Role of epigenetics in cancer initiation and progression.
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    Chapter 9 Cancer Stem Cells, Models of Study and Implications of Therapy Resistance Mechanisms
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    Chapter 10 The role of the Basal stem cell of the human breast in normal development and cancer.
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    Chapter 11 Breast cancer subtypes: two decades of journey from cell culture to patients.
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    Chapter 12 Parathyroid Hormone Related Protein (PTHrP) in Tumor Progression
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    Chapter 13 Mechanism of Radiation Carcinogenesis: Role of the TGFBI Gene and the Inflammatory Signaling Cascade.
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    Chapter 14 Histone deacetylase inhibitor: antineoplastic agent and radiation modulator.
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    Chapter 15 Human Fibroblasts for Large-Scale "Omics" Investigations of ATM Gene Function.
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    Chapter 16 Malignant Transformation of Human Skin Fibroblasts by Two Alternative Pathways
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    Chapter 17 A Novel Tumor Suppressor, REIC/Dkk-3 Gene Identified by Our In Vitro Transformation Model of Normal Human Fibroblasts Works as a Potent Therapeutic Anti-tumor Agent
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    Chapter 18 Erratum to: Comparative Proteomic Analysis of Mesenchymal Stem Cells Derived from Human Bone Marrow, Umbilical Cord and Placenta: Implication in the Migration
Attention for Chapter 8: Role of epigenetics in cancer initiation and progression.
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Citations

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Chapter title
Role of epigenetics in cancer initiation and progression.
Chapter number 8
Book title
Human Cell Transformation
Published in
Advances in experimental medicine and biology, January 2011
DOI 10.1007/978-1-4614-0254-1_8
Pubmed ID
21901621
Book ISBNs
978-1-4614-0253-4, 978-1-4614-0254-1
Authors

Flora Chik, Moshe Szyf, Shafaat A. Rabbani, Chik, Flora, Szyf, Moshe, Rabbani, Shafaat A.

Abstract

The epigenome which comprises DNA methylation, histone modifications, chromatin structures and non-coding RNAs controls gene expression patterns. In cancer cells, there are aberrant changes in the epigenome. The question in cancer epigenetics is that whether these changes are the cause of cell transformation, or rather the consequence of it. We will discuss the epigenetic phenomenon in cancer, as well as the recent interests in the epigenetic reprogramming events, and their implications in the cancer stem cell theory. We will also look at the progression of cancers as they become more aggressive, with focus on the role of epigenetics in tumor metastases exemplified with the urokinase plasminogen activator (uPA) system. Last but not least, with therapeutics intervention in mind, we will highlight the importance of balance in the design of epigenetic based anti-cancer therapeutic strategies.

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X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 44 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Unknown 43 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 13 30%
Student > Ph. D. Student 8 18%
Student > Master 5 11%
Student > Bachelor 4 9%
Lecturer > Senior Lecturer 1 2%
Other 2 5%
Unknown 11 25%
Readers by discipline Count As %
Medicine and Dentistry 11 25%
Agricultural and Biological Sciences 9 20%
Biochemistry, Genetics and Molecular Biology 8 18%
Unspecified 1 2%
Chemical Engineering 1 2%
Other 2 5%
Unknown 12 27%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 September 2011.
All research outputs
#18,295,723
of 22,651,245 outputs
Outputs from Advances in experimental medicine and biology
#3,273
of 4,902 outputs
Outputs of similar age
#159,884
of 180,239 outputs
Outputs of similar age from Advances in experimental medicine and biology
#24
of 42 outputs
Altmetric has tracked 22,651,245 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,902 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,239 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 42 others from the same source and published within six weeks on either side of this one. This one is in the 11th percentile – i.e., 11% of its contemporaries scored the same or lower than it.

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