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Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development

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Cover of 'Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development'

Table of Contents

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    Book Overview
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    Chapter 1 Rationale for the Effective Use of Pharmacokinetics and Pharmacodynamics in Early Drug Development
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    Chapter 2 The Case for Preclinical Pharmacodynamics
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    Chapter 3 Utility of Kinetic, Dynamic, and Metabolic Data in Nonclinical Pharmacology/Toxicology Studies
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    Chapter 4 Pharmacokinetics and Drug Metabolism in Animal Studies (ADME, Protein Binding, Mass Balance, Animal Models)
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    Chapter 5 Nonclinical Considerations: Disposition of Drugs
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    Chapter 6 Use of Acute Toxicity Data in the Design and Interpretation of Subchronic and Chronic Toxicity Studies
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    Chapter 7 Use of Pharmacokinetics and Pharmacodynamics in Preclinical Studies to Guide Dosage Escalation Schemes in Phase I Studies of Anticancer Drugs
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    Chapter 8 Use of Toxicokinetic Principles in Drug Development: Bridging Preclinical and Clinical Studies
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    Chapter 9 Preclinical Pharmacodynamics of Central Nervous System Active Agents
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    Chapter 10 Preclinical Pharmacodynamics of Antihypertensives
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    Chapter 11 Preclinical Pharmacodynamics of Anxiolytics: Effects of Chronic Benzodiazepine Administration
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    Chapter 12 Guidelines for Development of a New Diuretic Agent
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    Chapter 13 Preclinical Pharmacodynamics of Anti-Inflammatory Drugs
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    Chapter 14 The Role of Pharmacokinetics in the Drug Development Process
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    Chapter 15 Implementation of an Effective Pharmacokinetics Research Program in Industry
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    Chapter 16 Pharmacoepidemiology, Population Pharmacokinetics and New Drug Development
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    Chapter 17 Assessment of Pharmacokinetic Drug Interactions in Clinical Drug Development
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    Chapter 18 Pharmacokinetic/Pharmacodynamic Models and Methods
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    Chapter 19 Pharmacokinetic and Pharmacodynamic Modeling Applied to Anesthetic Drugs
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    Chapter 20 Pharmacodynamic/Pharmacokinetic Relationships for Rapidly Acting Drugs (NSAIDS) in Rheumatoid Arthritis: Problems and Preliminary Solutions
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    Chapter 21 The Value of Plasma-Warfarin Measurement
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    Chapter 22 Clinical Pharmacodynamics of Cardiovascular Agents: Focus on Sudden Cardiac Death
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    Chapter 23 The Benzodiazepines: Kinetic-Dynamic Relationships
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    Chapter 24 The Integration of Pharmacodynamics and Pharmacokinetics in Rational Drug Development
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    Chapter 25 Concentration-Controlled Trials: Basic Concepts, Design, and Implementation
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    Chapter 26 Opportunities for Integration of Pharmacokinetics, Pharmacodynamics and Toxicokinetics in Rational Drug Development
Attention for Chapter 25: Concentration-Controlled Trials: Basic Concepts, Design, and Implementation
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Chapter title
Concentration-Controlled Trials: Basic Concepts, Design, and Implementation
Chapter number 25
Book title
Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development
Published by
Springer US, February 1993
DOI 10.1007/978-1-4757-1520-0_25
Book ISBNs
978-1-4757-1522-4, 978-1-4757-1520-0
Authors

Lilly P. Sanathanan, Carl C. Peck

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