| Chapter title |
The epigenetic basis of adaptation and responses to environmental change: perspective on human reproduction.
|
|---|---|
| Chapter number | 6 |
| Book title |
Reproductive Sciences in Animal Conservation
|
| Published in |
Advances in experimental medicine and biology, January 2014
|
| DOI | 10.1007/978-1-4939-0820-2_6 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-0819-6, 978-1-4939-0820-2
|
| Authors |
Agustín F Fernández, Estela García Toraño, Rocío González Urdinguio, Abel Gayo Lana, Ignacio Arnott Fernández, Mario F Fraga, Agustín F. Fernández, Mario F. Fraga, Fernández, Agustín F., Toraño, Estela García, Urdinguio, Rocío González, Lana, Abel Gayo, Fernández, Ignacio Arnott, Fraga, Mario F. |
| Abstract |
Not only genetic but also epigenetic mechanisms regulate gene expression, cellular differentiation and development processes. Additionally, "environmental epigenetics" studies the interaction between the environment and the epigenome, and its potential role in the regulation of gene activity. Several studies have shown that the impact of environmental exposures on the epigenome takes on more importance during early fertilization and embryonic development, given that during these periods epigenetic reprogramming occurs and the new epigenetic profile of the offspring is established. Epigenetic alterations in the germline are especially relevant since they can be transmitted trans-generationally and could be associated with a wide range of diseases including several reproductive disorders. In this chapter we review some epigenetic mechanisms, focusing mainly on DNA methylation and histone modifications, which are related to reproductive aspects, and we discuss the controversies in the literature surrounding how environmental conditions, such as exposure to toxic substances or treatment with assisted reproductive techniques (ART), may be involved in epigenetic alterations that affect reproductive success. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 22 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 27% |
| Student > Ph. D. Student | 4 | 18% |
| Student > Master | 2 | 9% |
| Professor | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 7 | 32% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 32% |
| Biochemistry, Genetics and Molecular Biology | 4 | 18% |
| Medicine and Dentistry | 2 | 9% |
| Psychology | 1 | 5% |
| Computer Science | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 7 | 32% |