| Chapter title |
Tim-3, Lag-3, and TIGIT
|
|---|---|
| Chapter number | 62 |
| Book title |
Emerging Concepts Targeting Immune Checkpoints in Cancer and Autoimmunity
|
| Published in |
Current topics in microbiology and immunology, January 2017
|
| DOI | 10.1007/82_2017_62 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-968928-9, 978-3-31-968929-6
|
| Authors |
Nicole Joller, Vijay K. Kuchroo, Joller, Nicole, Kuchroo, Vijay K. |
| Abstract |
Co-inhibitory receptors play a key role in regulating T cell responses and maintaining immune homeostasis. Their inhibitory function prevents autoimmune responses but also restricts the ability of T cells to mount effective immune responses against tumors or persistent pathogens. T cells express a module of co-inhibitory receptors, which display great diversity in expression, structure, and function. Here, we focus on the co-inhibitory receptors Tim-3, Lag-3, and TIGIT and how they regulate T cell function, maintenance of self-tolerance, their role in regulating ongoing T cell responses at peripheral tissues, and their synergistic effects in regulating autoimmunity and antitumor responses. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 136 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 14% |
| Researcher | 17 | 13% |
| Student > Bachelor | 15 | 11% |
| Student > Master | 14 | 10% |
| Student > Doctoral Student | 9 | 7% |
| Other | 25 | 18% |
| Unknown | 37 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 29 | 21% |
| Medicine and Dentistry | 26 | 19% |
| Biochemistry, Genetics and Molecular Biology | 14 | 10% |
| Agricultural and Biological Sciences | 7 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 4% |
| Other | 11 | 8% |
| Unknown | 43 | 32% |