| Chapter title |
Innate and Adaptive Immune Cell Metabolism in Tumor Microenvironment
|
|---|---|
| Chapter number | 7 |
| Book title |
Immune Metabolism in Health and Tumor
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-94-024-1170-6_7 |
| Pubmed ID | |
| Book ISBNs |
978-9-40-241168-3, 978-9-40-241170-6
|
| Authors |
Duojiao Wu, Wu, Duojiao |
| Abstract |
During an immune response, leukocytes undergo major changes in growth and function that are tightly coupled to dynamic shifts in metabolic processes. Immunometabolism is an emerging field that investigates the interplay between immunological and metabolic processes. The immune system has a key role to play in controlling cancer initiation and progression. Increasing evidence indicates the immunosuppressive nature of the local environment in tumor. In tumor microenvironment, immune cells collectively adapt in a dynamic manner to the metabolic needs of cancer cells, thus prompting tumorigenesis and resistance to treatments. Here, we summarize the latest insights into the metabolic reprogramming of immune cells in tumor microenvironment and their potential roles in tumor progression and metastasis. Manipulating metabolic remodeling and immune responses may provide an exciting new option for cancer immunotherapy. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| United Kingdom | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 32 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 28% |
| Student > Bachelor | 5 | 16% |
| Researcher | 5 | 16% |
| Student > Master | 5 | 16% |
| Student > Doctoral Student | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 7 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 25% |
| Medicine and Dentistry | 4 | 13% |
| Immunology and Microbiology | 4 | 13% |
| Engineering | 2 | 6% |
| Agricultural and Biological Sciences | 1 | 3% |
| Other | 5 | 16% |
| Unknown | 8 | 25% |