Chapter title |
Transcriptional Regulation of T Cell Metabolism Reprograming
|
---|---|
Chapter number | 3 |
Book title |
Immune Metabolism in Health and Tumor
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1170-6_3 |
Pubmed ID | |
Book ISBNs |
978-9-40-241168-3, 978-9-40-241170-6
|
Authors |
Jinxia Zhang, Guoyu Bi, Yu Xia, Pingfei Li, Xiaofei Deng, Zhengping Wei, Xiang-Ping Yang, Zhang, Jinxia, Bi, Guoyu, Xia, Yu, Li, Pingfei, Deng, Xiaofei, Wei, Zhengping, Yang, Xiang-Ping |
Abstract |
T cell activation, differentiation, and function are tightly regulated by a complex network of transcription factors, epigenetic modifications, and signaling pathways of both TCR and cytokines. Over the past decade, it is increasingly clear that T cell immune responses are also regulated by their associated metabolic reprograming. Compared with relatively well-understood transcriptional regulation of T cell activation, differentiation, and function, less is known about the transcriptional regulation of T cell metabolic reprograming during T cell immune responses. In this review, we first describe how signaling pathways of TCR and cytokines regulate metabolic reprograming and then focus on transcription factors that control metabolic pathways and outcomes of T cell immune responses. A better understanding of T cell metabolic regulation will provide new strategies and targets for the treatment of T cell-related diseases. |
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France | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 21 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 6 | 29% |
Student > Postgraduate | 3 | 14% |
Researcher | 2 | 10% |
Student > Bachelor | 1 | 5% |
Unspecified | 1 | 5% |
Other | 1 | 5% |
Unknown | 7 | 33% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 5 | 24% |
Biochemistry, Genetics and Molecular Biology | 4 | 19% |
Agricultural and Biological Sciences | 2 | 10% |
Unspecified | 1 | 5% |
Environmental Science | 1 | 5% |
Other | 2 | 10% |
Unknown | 6 | 29% |