| Chapter title |
TGF-beta in dopamine neuron development, maintenance and neuroprotection.
|
|---|---|
| Chapter number | 8 |
| Book title |
Development and Engineering of Dopamine Neurons
|
| Published in |
Advances in experimental medicine and biology, September 2009
|
| DOI | 10.1007/978-1-4419-0322-8_8 |
| Pubmed ID | |
| Book ISBNs |
978-1-4419-0321-1, 978-1-4419-0322-8
|
| Authors |
Roussa E, von Bohlen und Halbach O, Krieglstein K, Roussa, Eleni, von Bohlen und Halback, Oliver, Krieglstein, Kerstin |
| Abstract |
ransforming growth factor betas (TGF-betas) are multifunctional cytokines with widespread distribution.In the nervous system the biological effects of TGF-beta cover regulation of proliferation, migration, differentiation, survival and death. Specifically, the effects of TGF-(3 on mesencephalic DAergic neurons extend from induction and specification of the dopaminergic phenotype via promotion of survival to neuroprotection in animal models of parkinsonism. Experimental in vitro and in vivo models have contributed to a better understanding of the putative mechanisms underlying the effects of TGF-beta on DAergic neurons and unravelled synergisms between members of the TGF-beta superfamily. In this chapter, we will review the literature available with focus on TGF-beta proper and glial cell-line-derived neurotrophic factor (GDNF). |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 7% |
| Luxembourg | 1 | 4% |
| Unknown | 24 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 26% |
| Professor | 4 | 15% |
| Student > Ph. D. Student | 3 | 11% |
| Student > Master | 2 | 7% |
| Librarian | 1 | 4% |
| Other | 3 | 11% |
| Unknown | 7 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 37% |
| Neuroscience | 3 | 11% |
| Medicine and Dentistry | 3 | 11% |
| Biochemistry, Genetics and Molecular Biology | 2 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 7 | 26% |