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Chapter title |
Synthetic Tumor-Specific Promoters for Transcriptional Regulation of Viral Replication
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Chapter number | 9 |
Book title |
Mammalian Synthetic Promoters
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Published in |
Methods in molecular biology, January 2017
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DOI | 10.1007/978-1-4939-7223-4_9 |
Pubmed ID | |
Book ISBNs |
978-1-4939-7221-0, 978-1-4939-7223-4
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Authors |
Maria Veronica Lopez, Eduardo G. Cafferata, Diego L. Viale, Osvaldo L. Podhajcer |
Abstract |
Here we describe a collection of methods that have been adapted to isolate and modify tumor-specific promoters (TSPs ) to drive viral replication for cancer therapy and other uses. We will describe as examples the secreted protein acidic and rich in cysteine (SPARC ) and the protease-activated receptor-1 (PAR-1) promoter. We outline strategies to select appropriate TSPs using bioinformatics resources and the methods utilized in their subsequent cloning, assessment of transcriptional activity, and their use in conditionally replicative oncolytic adenoviruses . |
Mendeley readers
The data shown below were compiled from readership statistics for 6 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 6 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 67% |
Student > Bachelor | 1 | 17% |
Student > Master | 1 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 2 | 33% |
Chemical Engineering | 1 | 17% |
Biochemistry, Genetics and Molecular Biology | 1 | 17% |
Immunology and Microbiology | 1 | 17% |
Unknown | 1 | 17% |