| Chapter title |
Innate immune responses to respiratory syncytial virus infection.
|
|---|---|
| Chapter number | 7 |
| Book title |
Challenges and Opportunities for Respiratory Syncytial Virus Vaccines
|
| Published in |
Current topics in microbiology and immunology, December 2013
|
| DOI | 10.1007/978-3-642-38919-1_7 |
| Pubmed ID | |
| Book ISBNs |
978-3-64-238918-4, 978-3-64-238919-1
|
| Authors |
Mukherjee S, Lukacs NW, Sumanta Mukherjee, Nicholas W. Lukacs, Mukherjee, Sumanta, Lukacs, Nicholas W. |
| Abstract |
The innate immune response has a critical role in the initial stages of respiratory syncytial virus (RSV) infection and provides important instructional control that determines the direction of the acquired immune response and the severity of subsequent disease. Contributions to innate immunity include responses initiated in epithelial cells, dendritic cells, and macrophages. The initiation and the intensity of the response depends upon the recognition of pathogen-associated molecular patterns (PAMPs) that activate various pattern recognition receptors (PRRs) such as toll-like receptors (TLR), RIG-I-like receptors (RLR), and NOD-like receptors (NLR), that induce innate cytokines and chemokines that promote inflammation and direct the recruitment of immune cells as well as promote anti-viral responses. In this review, we summarize the results of numerous studies that have characterized the innate immune responses that contribute to the RSV-induced responses and may be important considerations for the development of efficacious vaccine strategies. |
X Demographics
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|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 2% |
| Unknown | 52 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 10 | 19% |
| Student > Ph. D. Student | 9 | 17% |
| Student > Master | 9 | 17% |
| Student > Doctoral Student | 5 | 9% |
| Other | 2 | 4% |
| Other | 8 | 15% |
| Unknown | 10 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 12 | 23% |
| Agricultural and Biological Sciences | 8 | 15% |
| Medicine and Dentistry | 8 | 15% |
| Immunology and Microbiology | 7 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
| Other | 4 | 8% |
| Unknown | 13 | 25% |