Chapter title |
Influences of nanomaterials on the barrier function of epithelial cells.
|
---|---|
Chapter number | 3 |
Book title |
Nanomaterial
|
Published in |
Advances in experimental medicine and biology, April 2014
|
DOI | 10.1007/978-94-017-8739-0_3 |
Pubmed ID | |
Book ISBNs |
978-9-40-178738-3, 978-9-40-178739-0
|
Authors |
Ali S, Rytting E, Shariq Ali, Erik Rytting, Ali, Shariq, Rytting, Erik |
Abstract |
Recent advances in nanotechnology have led to exciting opportunities in medicine, energy, manufacturing, and other fields. Nevertheless, it is important to adequately assess the potential impacts of nanomaterial exposure. This chapter focuses on the interactions of nanomaterials with epithelial barriers in the lungs, intestine, kidneys, skin, and placenta. Methods for determining transepithelial electrical resistance and paracellular permeability are described. Effects on cell viability and barrier integrity depend on the chemical nature of the nanomaterial, nanoparticle size, surface coatings, and concentration. Disruption of tight junctions can affect permeability and interfere with normal regulatory processes of the epithelial barrier. Future research is needed to better understand the possibilities and the limits of novel approaches in nanotechnology. |
X Demographics
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United States | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 5 | 17% |
Researcher | 5 | 17% |
Student > Master | 4 | 13% |
Professor | 2 | 7% |
Student > Bachelor | 2 | 7% |
Other | 3 | 10% |
Unknown | 9 | 30% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 5 | 17% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
Chemistry | 3 | 10% |
Engineering | 3 | 10% |
Biochemistry, Genetics and Molecular Biology | 1 | 3% |
Other | 4 | 13% |
Unknown | 11 | 37% |