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Natural Products in Cancer Prevention and Therapy

Overview of attention for book
Attention for Chapter 343: Chemoprevention of Esophageal Squamous Cell Carcinoma with Berries.
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Chapter title
Chemoprevention of Esophageal Squamous Cell Carcinoma with Berries.
Chapter number 343
Book title
Natural Products in Cancer Prevention and Therapy
Published in
Topics in current chemistry, July 2012
DOI 10.1007/128_2012_343
Pubmed ID
Book ISBNs
978-3-64-234574-6, 978-3-64-234575-3
Authors

Gary D. Stoner, Li-Shu Wang

Editors

John M. Pezzuto, Nanjoo Suh

Abstract

Esophageal squamous cell carcinoma (SCC) is responsible for about one-seventh of all cancer-related mortality worldwide. This disease has a multifactorial etiology involving numerous environmental, genetic, and dietary factors. The 5-year survival from esophageal SCC is poor because the disease has usually metastasized at the time of diagnosis. Clinical investigations have shown that primary chemoprevention of this disease is feasible; however, only a few agents have shown efficacy. The Fischer 344 (F-344) rat model of esophageal SCC has been used extensively to investigate the pathophysiology of the disease and to identify chemopreventive agents of potential use in human trials. Multiple compounds that inhibit tumor initiation and/or tumor progression in the rat model have been identified. These include the isothiocyanates which inhibit the metabolic activation of esophageal carcinogens and agents that inhibit the progression of dysplastic lesions to cancer including inhibitors of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), vascular endothelial growth factor (VEGF), and c-Jun (a component of activator protein-1 [AP-1]). The present review deals principally with the use of berry preparations for the prevention of esophageal SCC in rodents, and summarizes recent data from a human clinical trial in China. Our results suggest that the use of berry preparations might be a practical approach to the prevention of esophageal SCC in China and, potentially, other high risk regions for this disease.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 9 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 9 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 22%
Student > Master 2 22%
Researcher 2 22%
Student > Bachelor 1 11%
Unknown 2 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 3 33%
Biochemistry, Genetics and Molecular Biology 2 22%
Computer Science 1 11%
Unknown 3 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 July 2012.
All research outputs
#20,160,460
of 22,669,724 outputs
Outputs from Topics in current chemistry
#130
of 148 outputs
Outputs of similar age
#148,090
of 164,352 outputs
Outputs of similar age from Topics in current chemistry
#6
of 7 outputs
Altmetric has tracked 22,669,724 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 148 research outputs from this source. They receive a mean Attention Score of 4.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 164,352 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.