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Natural Products in Cancer Prevention and Therapy

Overview of attention for book
Attention for Chapter 345: Cancer Prevention by Different Forms of Tocopherols.
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Chapter title
Cancer Prevention by Different Forms of Tocopherols.
Chapter number 345
Book title
Natural Products in Cancer Prevention and Therapy
Published in
Topics in current chemistry, July 2012
DOI 10.1007/128_2012_345
Pubmed ID
Book ISBNs
978-3-64-234574-6, 978-3-64-234575-3
Authors

Yang CS, Suh N, Chung S. Yang, Nanjoo Suh

Editors

John M. Pezzuto, Nanjoo Suh

Abstract

Many epidemiological studies have suggested that a low vitamin E nutritional status is associated with increased cancer risk. However, several recent large-scale human trials with high doses of α-tocopherol (α-T) have produced disappointing results. This points out the need for a better understanding of the biological activities of the different forms of tocopherols. Using a naturally occurring tocopherol mixture (γ-TmT) that is rich in γ-T, we demonstrated the inhibition of chemically induced lung, colon, and mammary cancer formation as well as the growth of xenograft tumors derived from human lung and prostate cancer cells. This broad anticancer activity of γ-TmT has been attributed mainly to the trapping of reactive oxygen and nitrogen species and inhibition of arachidonic acid metabolism. Activation of peroxisome proliferator-activated receptor γ (PPARγ) and the inhibition of estrogen signaling have also been observed in the inhibition of mammary cancer development. δ-T has been shown to be more active than γ-T in inhibiting the growth of human lung cancer cells in a xenograft tumor model and the development of aberrant crypt foci in azoxymethane-treated rats, whereas α-T is not effective in these models. The higher inhibitory activities of δ-T and γ-T (than α-T) are proposed to be due to their trapping of reactive nitrogen species and their capacity to generate side-chain degradation products, which retain the intact chromanol ring structure and could have cancer preventive activities.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
India 1 8%
United States 1 8%
Unknown 11 85%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 38%
Student > Ph. D. Student 4 31%
Other 2 15%
Student > Bachelor 2 15%
Professor 1 8%
Other 2 15%
Readers by discipline Count As %
Medicine and Dentistry 3 23%
Biochemistry, Genetics and Molecular Biology 3 23%
Agricultural and Biological Sciences 3 23%
Pharmacology, Toxicology and Pharmaceutical Science 1 8%
Business, Management and Accounting 1 8%
Other 4 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 March 2013.
All research outputs
#15,342,903
of 17,359,532 outputs
Outputs from Topics in current chemistry
#113
of 131 outputs
Outputs of similar age
#135,833
of 158,154 outputs
Outputs of similar age from Topics in current chemistry
#1
of 1 outputs
Altmetric has tracked 17,359,532 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 131 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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