Chapter title |
TRPC Channels and Epilepsy
|
---|---|
Chapter number | 11 |
Book title |
Transient Receptor Potential Canonical Channels and Brain Diseases
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1088-4_11 |
Pubmed ID | |
Book ISBNs |
978-9-40-241086-0, 978-9-40-241088-4, 978-9-40-241086-0, 978-9-40-241088-4
|
Authors |
Fang Zheng, Zheng, Fang |
Abstract |
Accumulating evidence suggest that TRPC channels play critical roles in various aspects of epileptogenesis. TRPC1/4 channels are major contributors to nonsynaptically derived epileptiform burst firing in the CA1 and the lateral septum. TRPC7 channels play a critical role in synaptically derived epileptiform burst firing. The reduction of spontaneous epileptiform bursting in the CA3 is correlated to a reduction in pilocarpine-induced SE in vivo in TRPC7 knockout mice. TRPC channels are also significant contributors to SE-induced neuronal cell death. Although the pilocarpine-induced SE itself is not significantly reduced, the SE-induced neuronal cell death is significantly reduced in the CA1 and the lateral septum, indicating that TRPC1/4 channels directly contribute to SE-induced neuronal cell death. Genetic ablation of TRPC5 also reduces SE-induced neuronal cell death in the CA1 and CA3 areas of the hippocampus. |
X Demographics
As of 1 July 2024, you may notice a temporary increase in the numbers of X profiles with Unknown location. Click here to learn more.
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 27% |
Student > Master | 2 | 18% |
Student > Doctoral Student | 1 | 9% |
Librarian | 1 | 9% |
Student > Ph. D. Student | 1 | 9% |
Other | 1 | 9% |
Unknown | 2 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 27% |
Biochemistry, Genetics and Molecular Biology | 3 | 27% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 9% |
Nursing and Health Professions | 1 | 9% |
Neuroscience | 1 | 9% |
Other | 0 | 0% |
Unknown | 2 | 18% |