Chapter title |
TRPC Channels and Neuron Development, Plasticity, and Activities
|
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Chapter number | 9 |
Book title |
Transient Receptor Potential Canonical Channels and Brain Diseases
|
Published in |
Advances in experimental medicine and biology, January 2017
|
DOI | 10.1007/978-94-024-1088-4_9 |
Pubmed ID | |
Book ISBNs |
978-9-40-241086-0, 978-9-40-241088-4, 978-9-40-241086-0, 978-9-40-241088-4
|
Authors |
Yilin Tai, Yichang Jia, Tai, Yilin, Jia, Yichang |
Abstract |
In this chapter, we mainly focus on the functions of TRPC channels in brain development, including neural progenitor proliferation, neurogenesis, neuron survival, axon guidance, dendritic morphology, synaptogenesis, and neural plasticity. We also notice emerging advances in understanding the functions of TRPC channels in periphery, especially their functions in sensation and nociception in dorsal root ganglion (DRG). Because TRPC channels are expressed in all major types of glial cells, which account for at least half of total cells in the brain, TRPC channels may act as modulators for glial functions as well. The future challenges for studying these channels could be (1) the detailed protein structures of these channels, (2) their cell type-specific functions, (3) requirement for their specific blockers or activators, and (4) change in the channel conformation in the brain. |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
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Unknown | 6 | 100% |
Demographic breakdown
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Student > Ph. D. Student | 2 | 33% |
Student > Bachelor | 2 | 33% |
Researcher | 1 | 17% |
Student > Doctoral Student | 1 | 17% |
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Biochemistry, Genetics and Molecular Biology | 4 | 67% |
Agricultural and Biological Sciences | 1 | 17% |
Neuroscience | 1 | 17% |