| Chapter title |
Reconstitution of Protein Dynamics Involved in Bacterial Cell Division
|
|---|---|
| Chapter number | 15 |
| Book title |
Prokaryotic Cytoskeletons
|
| Published in |
Sub cellular biochemistry, May 2017
|
| DOI | 10.1007/978-3-319-53047-5_15 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-953045-1, 978-3-31-953047-5
|
| Authors |
Martin Loose, Katja Zieske, Petra Schwille |
| Editors |
Jan Löwe, Linda A. Amos |
| Abstract |
Even simple cells like bacteria have precisely regulated cellular anatomies, which allow them to grow, divide and to respond to internal or external cues with high fidelity. How spatial and temporal intracellular organization in prokaryotic cells is achieved and maintained on the basis of locally interacting proteins still remains largely a mystery. Bulk biochemical assays with purified components and in vivo experiments help us to approach key cellular processes from two opposite ends, in terms of minimal and maximal complexity. However, to understand how cellular phenomena emerge, that are more than the sum of their parts, we have to assemble cellular subsystems step by step from the bottom up. Here, we review recent in vitro reconstitution experiments with proteins of the bacterial cell division machinery and illustrate how they help to shed light on fundamental cellular mechanisms that constitute spatiotemporal order and regulate cell division. |
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