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Mitophagy

Overview of attention for book
Cover of 'Mitophagy'

Table of Contents

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    Book Overview
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    Chapter 7 Induction of PINK1/Parkin-Mediated Mitophagy
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    Chapter 8 The Use of Correlative Light-Electron Microscopy (CLEM) to Study PINK1/Parkin-Mediated Mitophagy
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    Chapter 9 Monitoring Mitochondrial Changes by Alteration of the PINK1-Parkin Signaling in Drosophila
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    Chapter 10 Assessment of Mitophagy in iPS Cell-Derived Neurons
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    Chapter 11 Investigation of Yeast Mitophagy with Fluorescence Microscopy and Western Blotting
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    Chapter 12 MitoPho8Δ60 Assay as a Tool to Quantitatively Measure Mitophagy Activity
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    Chapter 13 Mitophagy in Yeast: A Screen of Mitophagy-Deficient Mutants
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    Chapter 14 Flow Cytometer Monitoring of Bnip3- and Bnip3L/Nix-Dependent Mitophagy
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    Chapter 15 Exploring MicroRNAs on NIX-Dependent Mitophagy
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    Chapter 16 Monitoring of Atg5-Independent Mitophagy
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    Chapter 17 Monitoring of Paternal Mitochondrial Degradation in Caenorhabditis elegans
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    Chapter 18 Monitoring Mitophagy During Aging in Caenorhabditis elegans
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    Chapter 19 Detection of Hypoxia-Induced and Iron Depletion-Induced Mitophagy in Mammalian Cells
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    Chapter 20 Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells
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    Chapter 38 Short Overview
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    Chapter 39 Observation of Parkin-Mediated Mitophagy in Pancreatic β-Cells
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    Chapter 40 Monitoring of Iron Depletion-Induced Mitophagy in Pathogenic Yeast
  19. Altmetric Badge
    Chapter 156 Dopaminergic Neuron-Specific Autophagy-Deficient Mice
Attention for Chapter 39: Observation of Parkin-Mediated Mitophagy in Pancreatic β-Cells
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Chapter title
Observation of Parkin-Mediated Mitophagy in Pancreatic β-Cells
Chapter number 39
Book title
Mitophagy
Published in
Methods in molecular biology, May 2017
DOI 10.1007/7651_2017_39
Pubmed ID
Book ISBNs
978-1-4939-7749-9, 978-1-4939-7750-5
Authors

Atsushi Hoshino, Satoaki Matoba, Hoshino, Atsushi, Matoba, Satoaki

Abstract

Mitophagy is a cellular process of autophagy-based mitochondrial degradation that eliminates dysfunctional mitochondria and ensures cellular homeostasis. In pancreatic islet β-cells, mitochondria play a pivotal role in glucose-stimulated insulin secretion through ATP production from glucose oxidation. Recent studies have shown that impaired mitophagy and the subsequent mitochondrial compromise contribute to β-cell dysfunction and glucose intolerance. In this chapter, we describe a protocol to monitor Parkin-mediated mitophagy in pancreatic MIN6 β-cells using flow cytometry and a pH-sensitive fluorophore, mKeima.

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Mendeley readers

The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 2 29%
Researcher 1 14%
Other 1 14%
Student > Master 1 14%
Unknown 2 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 57%
Pharmacology, Toxicology and Pharmaceutical Science 1 14%
Unknown 2 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 May 2017.
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#20,418,183
of 22,968,808 outputs
Outputs from Methods in molecular biology
#9,923
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Outputs of similar age
#270,614
of 310,917 outputs
Outputs of similar age from Methods in molecular biology
#233
of 280 outputs
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