↓ Skip to main content

Therapeutic Applications of Ribozymes and Riboswitches

Overview of attention for book
Cover of 'Therapeutic Applications of Ribozymes and Riboswitches'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Identification of regulatory RNA in bacterial genomes by genome-scale mapping of transcription start sites.
  3. Altmetric Badge
    Chapter 2 Screening Inhibitory Potential of Anti-HIV RT RNA Aptamers
  4. Altmetric Badge
    Chapter 3 Design and Evaluation of Clinically Relevant SOFA-HDV Ribozymes Targeting HIV RNA
  5. Altmetric Badge
    Chapter 4 Directing RNase P-Mediated Cleavage of Target mRNAs by Engineered External Guide Sequences in Cultured Cells
  6. Altmetric Badge
    Chapter 5 Design and Analysis of Hammerhead Ribozyme Activity Against an Artificial Gene Target
  7. Altmetric Badge
    Chapter 6 Knockdown Strategies for the Study of Proprotein Convertases and Proliferation in Prostate Cancer Cells
  8. Altmetric Badge
    Chapter 7 Use of Tumor-Targeting Trans -Splicing Ribozyme for Cancer Treatment
  9. Altmetric Badge
    Chapter 8 Characterization of Hairpin Ribozyme Reactions
  10. Altmetric Badge
    Chapter 9 Finding Instances of Riboswitches and Ribozymes by Homology Search of Structured RNA with Infernal
  11. Altmetric Badge
    Chapter 10 Structure-Based Virtual Screening for the Identification of RNA-Binding Ligands
  12. Altmetric Badge
    Chapter 11 Probing Riboswitch Binding Sites with Molecular Docking, Focused Libraries, and In-line Probing Assays
  13. Altmetric Badge
    Chapter 12 Discovery of Small Molecule Modifiers of microRNAs for the Treatment of HCV Infection
  14. Altmetric Badge
    Chapter 13 Bacterial Flavin Mononucleotide Riboswitches as Targets for Flavin Analogs
  15. Altmetric Badge
    Chapter 14 Construction and Application of Riboswitch-Based Sensors That Detect Metabolites Within Bacterial Cells
  16. Altmetric Badge
    Chapter 15 Screening Assays to Identify Artificial glmS Ribozyme Activators
  17. Altmetric Badge
    Chapter 16 Analysis of Riboswitch Structure and Ligand Binding Using Small-Angle X-ray Scattering (SAXS)
  18. Altmetric Badge
    Chapter 17 Use of SHAPE to Select 2AP Substitution Sites for RNA–Ligand Interactions and Dynamics Studies
  19. Altmetric Badge
    Chapter 18 Cell Internalization SELEX: In Vitro Selection for Molecules That Internalize into Cells
  20. Altmetric Badge
    Chapter 19 Therapeutic Applications of Ribozymes and Riboswitches
Attention for Chapter 1: Identification of regulatory RNA in bacterial genomes by genome-scale mapping of transcription start sites.
Altmetric Badge

About this Attention Score

  • Good Attention Score compared to outputs of the same age (72nd percentile)
  • High Attention Score compared to outputs of the same age and source (83rd percentile)

Mentioned by

twitter
6 X users
googleplus
1 Google+ user

Citations

dimensions_citation
1 Dimensions

Readers on

mendeley
11 Mendeley
citeulike
1 CiteULike
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Identification of regulatory RNA in bacterial genomes by genome-scale mapping of transcription start sites.
Chapter number 1
Book title
Therapeutic Applications of Ribozymes and Riboswitches
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-62703-730-3_1
Pubmed ID
Book ISBNs
978-1-62703-729-7, 978-1-62703-730-3
Authors

Navjot Singh, Joseph T Wade, Joseph T. Wade, Singh, Navjot, Wade, Joseph T.

Abstract

The ability to map transcription start sites is critical for studies of gene regulation and for identification of novel RNAs. Conventional RNA-seq is often insufficient for identification of transcription start sites due to low coverage and/or RNA processing events. We have developed a highly sensitive, genome-scale method for detection of transcription start sites in bacteria. This method uses deep sequencing of cDNA libraries to identify transcription start sites with strand specificity at nucleotide resolution. Here, we describe the application of this method for transcription start site identification in Escherichia coli.

X Demographics

X Demographics

The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 18%
Unknown 9 82%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 36%
Other 2 18%
Researcher 2 18%
Professor 1 9%
Student > Master 1 9%
Other 1 9%
Readers by discipline Count As %
Agricultural and Biological Sciences 5 45%
Biochemistry, Genetics and Molecular Biology 4 36%
Unspecified 1 9%
Social Sciences 1 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2014.
All research outputs
#7,480,247
of 24,594,795 outputs
Outputs from Methods in molecular biology
#2,238
of 13,828 outputs
Outputs of similar age
#84,793
of 316,481 outputs
Outputs of similar age from Methods in molecular biology
#95
of 561 outputs
Altmetric has tracked 24,594,795 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 13,828 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 83% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 316,481 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 561 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 83% of its contemporaries.