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Trinucleotide Repeat Protocols

Overview of attention for book
Cover of 'Trinucleotide Repeat Protocols'

Table of Contents

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    Book Overview
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    Chapter 1 A brief history of triplet repeat diseases.
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    Chapter 2 Huntington's Disease and Cell Therapies: Past, Present, and Future.
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    Chapter 3 Transcranial Two-Photon Imaging of Synaptic Structures in the Cortex of Awake Head-Restrained Mice
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    Chapter 4 In Vivo Imaging of Synapse Plasticity in the Mouse Motor Cortex
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    Chapter 5 Pluripotent Hybrid Stem Cells from Transgenic Huntington’s Disease Monkey
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    Chapter 6 Mesenchymal Stem Cells for Trinucleotide Repeat Disorders
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    Chapter 7 Trinucleotide Repeat Protocols
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    Chapter 8 Purification of dFMR1-Containing Complexes Using Tandem Affinity Purification.
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    Chapter 9 Combined FISH and Immunofluorescent Staining Methods to Co-localize Proteins and mRNA in Neurons and Brain Tissue
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    Chapter 10 Epigenetic Modifications of the FMR1 Gene
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    Chapter 11 The CGG Repeat and the FMR1 Gene
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    Chapter 12 Study of Oxidative Damage and Antioxidant Systems in Two Huntington’s Disease Rodent Models
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    Chapter 13 Regulation of Ataxin-1 Phosphorylation and Its Impact on Biology
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    Chapter 14 Towards Understanding Region-Specificity of Triplet Repeat Diseases: Coupled Immunohistology and Mass Spectrometry Imaging
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    Chapter 15 Antibodies and Intrabodies Against Huntingtin: Production and Screening of Monoclonals and Single-Chain Recombinant Forms
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    Chapter 16 Cell Recovery from DM1 Transgenic Mouse Tissue to Study (CTG) n Instability and DM1 Pathogenesis
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    Chapter 17 Markerless Modification of Trinucleotide Repeat Loci in BACs
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    Chapter 18 DRPLA: Recent Advances in Research Using Transgenic Mouse Models
Attention for Chapter 6: Mesenchymal Stem Cells for Trinucleotide Repeat Disorders
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Chapter title
Mesenchymal Stem Cells for Trinucleotide Repeat Disorders
Chapter number 6
Book title
Trinucleotide Repeat Protocols
Published in
Methods in molecular biology, December 2013
DOI 10.1007/978-1-62703-411-1_6
Pubmed ID
23754220
Book ISBNs
978-1-62703-410-4, 978-1-62703-411-1
Authors

Geralyn Annett, Gerhard Bauer, Jan A. Nolta, Annett, Geralyn, Bauer, Gerhard, Nolta, Jan A.

Abstract

Mesenchymal stem cells/marrow stromal cells (MSCs) are ideally suited for cellular therapy due to their ease of isolation, manipulation, and strong safety profile in the clinic. They can be expanded from normal qualified human donors in large quantities and can be infused without tissue matching, since they shield themselves from the immune system. The ability to be transplanted without tissue matching has allowed large multicenter trials to be conducted with direct comparison of the same batches of MSCs, without adverse events or rejection reactions. MSCs are now approved as drugs in several countries outside of the USA. MSCs can be genetically modified to provide sustained and long-term delivery of growth factors at supraphysiological levels. Gene-modified MSCs are in clinical trials for the treatment of stroke and are under consideration for the treatment of neurodegenerative disorders such as Huntington's disease.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 18 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 6%
Unknown 17 94%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 17%
Student > Master 3 17%
Professor 2 11%
Student > Ph. D. Student 1 6%
Other 1 6%
Other 2 11%
Unknown 6 33%
Readers by discipline Count As %
Medicine and Dentistry 3 17%
Biochemistry, Genetics and Molecular Biology 2 11%
Agricultural and Biological Sciences 2 11%
Psychology 1 6%
Philosophy 1 6%
Other 4 22%
Unknown 5 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2013.
All research outputs
#18,357,514
of 22,736,112 outputs
Outputs from Methods in molecular biology
#7,854
of 13,086 outputs
Outputs of similar age
#231,719
of 307,039 outputs
Outputs of similar age from Methods in molecular biology
#289
of 574 outputs
Altmetric has tracked 22,736,112 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,086 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 307,039 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 574 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.

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