Chapter title |
Markers for Anti-cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Therapy in Melanoma.
|
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Chapter number | 6 |
Book title |
Molecular Diagnostics for Melanoma
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Published in |
Methods in molecular biology, January 2014
|
DOI | 10.1007/978-1-62703-727-3_6 |
Pubmed ID | |
Book ISBNs |
978-1-62703-726-6, 978-1-62703-727-3
|
Authors |
Michael A Postow, Jianda Yuan, Shigehisa Kitano, Alexander M Lesokhin, Jedd D Wolchok, Michael A. Postow, Alexander M. Lesokhin, Jedd D. Wolchok, Postow, Michael A., Yuan, Jianda, Kitano, Shigehisa, Lesokhin, Alexander M., Wolchok, Jedd D. |
Abstract |
Therapeutic strategies that block Cytotoxic T lymphocyte antigen-4 (CTLA-4) enhance antitumor immunity and prolong the lives of patients with metastatic melanoma. However, only a subset of patients benefit, and responses are often delayed due to heterogeneous response kinetics. Ongoing monitoring of the immunologic effects of therapy and correlating these immunologic changes with patient outcomes continue to be important goals to better identify possible mechanisms of clinical activity of these agents. This chapter introduces the major areas of investigation in monitoring patients treated with CTLA-4 blockade and provides specific details of our experience performing selected assays. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 4 | 16% |
Student > Ph. D. Student | 3 | 12% |
Researcher | 3 | 12% |
Other | 2 | 8% |
Professor > Associate Professor | 2 | 8% |
Other | 3 | 12% |
Unknown | 8 | 32% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 20% |
Agricultural and Biological Sciences | 5 | 20% |
Immunology and Microbiology | 4 | 16% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Chemistry | 1 | 4% |
Other | 0 | 0% |
Unknown | 8 | 32% |