Chapter title |
B7-h abnormalities in melanoma and clinical relevance.
|
---|---|
Chapter number | 19 |
Book title |
Molecular Diagnostics for Melanoma
|
Published in |
Methods in molecular biology, January 2014
|
DOI | 10.1007/978-1-62703-727-3_19 |
Pubmed ID | |
Book ISBNs |
978-1-62703-726-6, 978-1-62703-727-3
|
Authors |
Barbara Seliger, Seliger, Barbara |
Abstract |
Melanoma have been shown to escape immune surveillance by different mechanisms such as loss of HLA class I antigens, upregulation of nonclassical HLA-G antigen and Fas, increased secretion of immune suppressive cytokines and metabolites as well as altered expression of co-stimulatory and coinhibitory signals. Recently, an important role of B7-H1 and B7-H4 in the immune escape of melanoma has been described. High mRNA and/or protein expression levels of these coinhibitory molecules were detected in both melanoma cell lines and melanoma lesions when compared to melanocytes. However, their clinical relevance is currently controversially discussed regarding a correlation of B7-H family members with tumor grading and staging as well as survival of patients in melanoma. |
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