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Molecular Diagnostics for Melanoma

Overview of attention for book
Cover of 'Molecular Diagnostics for Melanoma'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Novel insights/translational implication from the emerging biology of melanoma.
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    Chapter 2 Emerging clinical issues in melanoma in the molecularly targeted era.
  4. Altmetric Badge
    Chapter 3 Integrating molecular biomarkers into current clinical management in melanoma.
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    Chapter 4 Advances in adjuvant therapy: potential for prognostic and predictive biomarkers.
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    Chapter 5 Immunologic Monitoring of Cancer Vaccine Trials Using the ELISPOT Assay
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    Chapter 6 Markers for Anti-cytotoxic T-lymphocyte Antigen 4 (CTLA-4) Therapy in Melanoma.
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    Chapter 7 Marker utility for combination therapy.
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    Chapter 8 Assaying for BRAF V600E in Tissue and Blood in Melanoma.
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    Chapter 9 Selecting Patients for KIT Inhibition in Melanoma.
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    Chapter 10 Detecting Mechanisms of Acquired BRAF Inhibitor Resistance in Melanoma.
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    Chapter 11 Current status of diagnostic and prognostic markers in melanoma.
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    Chapter 12 Chromosomal copy number analysis in melanoma diagnostics.
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    Chapter 13 Construction and analysis of multiparameter prognostic models for melanoma outcome.
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    Chapter 14 Immunohistochemical diagnostic and prognostic markers for melanoma.
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    Chapter 15 Lymphatic Invasion as a Prognostic Biomarker in Primary Cutaneous Melanoma
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    Chapter 16 Tumor-infiltrating lymphocytes and their significance in melanoma prognosis.
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    Chapter 17 Pathological Staging of Melanoma
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    Chapter 18 Genotyping of Human Leukocyte Antigen (HLA) Ancestral Haplotypes as Prognostic Marker in Cancer Using PCR Analysis
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    Chapter 19 B7-h abnormalities in melanoma and clinical relevance.
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    Chapter 20 Melanoma susceptibility genes and risk assessment.
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    Chapter 21 Clinical, pathologic, and imaging features and biological markers of uveal melanoma.
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    Chapter 22 A prognostic test to predict the risk of metastasis in uveal melanoma based on a 15-gene expression profile.
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    Chapter 23 Molecular karyotyping for detection of prognostic markers in fine needle aspiration biopsy samples of uveal melanoma.
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    Chapter 24 ERBB4 Mutation Analysis: Emerging Molecular Target for Melanoma Treatment.
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    Chapter 25 Epigenetic markers of prognosis in melanoma.
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    Chapter 26 Isolation of melanoma cell subpopulations using negative selection.
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    Chapter 27 Circulating tumor cells as prognostic biomarkers in cutaneous melanoma patients.
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    Chapter 28 Detection of Chondroitin Sulfate Proteoglycan 4 (CSPG4) in Melanoma.
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    Chapter 29 Targeting Damage-Associated Molecular Pattern Molecules (DAMPs) and DAMP Receptors in Melanoma
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    Chapter 30 The Clinical Use of PET/CT in the Evaluation of Melanoma.
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    Chapter 31 Immune System Functional Pathway Analysis Using Single Cell Network Profiling (SCNP): A Novel Tool in Cancer Immunotherapy.
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    Chapter 32 Quantitative and Spatial Image Analysis of Tumor and Draining Lymph Nodes Using Immunohistochemistry and High-Resolution Multispectral Imaging to Predict Metastasis
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    Chapter 33 COLD-PCR Enriches Low-Level Variant DNA Sequences and Increases the Sensitivity of Genetic Testing.
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    Chapter 34 Isolation of Circulating MicroRNAs from Microvesicles Found in Human Plasma.
  36. Altmetric Badge
    Chapter 35 Detection of circulating tumor cells by photoacoustic flowmetry.
  37. Altmetric Badge
    Chapter 36 Statistical Design and Evaluation of Biomarker Studies
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    Chapter 37 Tissue resources for clinical use and marker studies in melanoma.
Attention for Chapter 16: Tumor-infiltrating lymphocytes and their significance in melanoma prognosis.
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  • Good Attention Score compared to outputs of the same age and source (67th percentile)

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Chapter title
Tumor-infiltrating lymphocytes and their significance in melanoma prognosis.
Chapter number 16
Book title
Molecular Diagnostics for Melanoma
Published in
Methods in molecular biology, January 2014
DOI 10.1007/978-1-62703-727-3_16
Pubmed ID
24258985
Book ISBNs
978-1-62703-726-6, 978-1-62703-727-3
Authors

Tobias Schatton, Richard A Scolyer, John F Thompson, Martin C Mihm, Richard A. Scolyer, John F. Thompson, Martin C. Mihm, Schatton, Tobias, Scolyer, Richard A., Thompson, John F., Mihm, Martin C.

Abstract

The role of the tumor-infiltrating lymphocyte (TIL) and its relationship to prognosis has been most extensively studied in malignant melanoma. The purpose of this chapter is to discuss in depth the immunobiology and molecular aspects of lymphocyte function in general and particularly TIL function in the context of antimelanoma immunity. Emphasis is placed upon the role of these inflammatory mediators in the enhancement and impairment of progression of this often fatal human cancer. In addition, the analysis of TILs in melanoma and their direct relationship to prognosis as well as their effect on the positivity of the sentinel lymph node will be discussed. Furthermore, details of lymph node responses to metastatic melanomas and their prognostic significance will be clarified. Finally, the importance of TILs for the evaluation of therapeutic response and how TIL immunobiology could critically inform the design of novel melanoma immunotherapeutic protocols will be elucidated.

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X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 1 2%
Brazil 1 2%
Unknown 58 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 13%
Student > Ph. D. Student 8 13%
Researcher 7 12%
Student > Doctoral Student 5 8%
Student > Master 5 8%
Other 9 15%
Unknown 18 30%
Readers by discipline Count As %
Medicine and Dentistry 22 37%
Biochemistry, Genetics and Molecular Biology 4 7%
Immunology and Microbiology 4 7%
Agricultural and Biological Sciences 3 5%
Veterinary Science and Veterinary Medicine 3 5%
Other 5 8%
Unknown 19 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2014.
All research outputs
#14,766,517
of 22,731,677 outputs
Outputs from Methods in molecular biology
#4,666
of 13,085 outputs
Outputs of similar age
#183,005
of 305,170 outputs
Outputs of similar age from Methods in molecular biology
#181
of 594 outputs
Altmetric has tracked 22,731,677 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,085 research outputs from this source. They receive a mean Attention Score of 3.3. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 305,170 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 38th percentile – i.e., 38% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 594 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.

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