RNA Methylation
Springer New York
Chapter title |
Statistical Methods for Transcriptome-Wide Analysis of RNA Methylation by Bisulfite Sequencing
|
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Chapter number | 11 |
Book title |
RNA Methylation
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Published in |
Methods in molecular biology, March 2017
|
DOI | 10.1007/978-1-4939-6807-7_11 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6805-3, 978-1-4939-6807-7
|
Authors |
Parker, Brian J., Brian J. Parker |
Editors |
Alexandra Lusser |
Abstract |
For the transcriptome-wide detection and quantification of the 5-methylcytosine (m(5)C) methylation modification of RNA, one experimental approach is via bisulfite conversion. In this chapter we discuss statistical methods, and a corresponding computational pipeline, to perform transcriptome-wide differential m(5)C methylation analysis between RNA samples, specialized for this assay. |
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