| Chapter title |
In Vivo Model of Small Intestine
|
|---|---|
| Chapter number | 17 |
| Book title |
Organ Regeneration
|
| Published in |
Methods in molecular biology, March 2017
|
| DOI | 10.1007/978-1-4939-6949-4_17 |
| Pubmed ID | |
| Book ISBNs |
978-1-4939-6947-0, 978-1-4939-6949-4
|
| Authors |
Mahe M. Maxime, Nicole E. Brown, Holly M. Poling, Helmrath A. Michael, Maxime M. Mahe, Michael A. Helmrath, Mahe, Maxime M., Brown, Nicole E., Poling, Holly M., Helmrath, Michael A. |
| Editors |
Takashi Tsuji |
| Abstract |
The utilization of human pluripotent stem cells (hPSCs) offers new avenues in the generation of organs and opportunities to understand development and diseases. The hPSC-derived human intestinal organoids (HIOs) provide a new tool to gain insights in small intestinal development, physiology, and associated diseases. Herein, we provide a method for orthotropic transplantation of HIOs in immunocompromised mice. This method highlights the specific steps to successful engraftment and provides insight into the study of bioengineered human small intestine. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 3 | 12% |
| Student > Bachelor | 3 | 12% |
| Student > Doctoral Student | 3 | 12% |
| Student > Ph. D. Student | 2 | 8% |
| Student > Master | 2 | 8% |
| Other | 5 | 19% |
| Unknown | 8 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 5 | 19% |
| Engineering | 4 | 15% |
| Agricultural and Biological Sciences | 3 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Unspecified | 1 | 4% |
| Other | 3 | 12% |
| Unknown | 9 | 35% |