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Organ Regeneration

Overview of attention for book
Cover of 'Organ Regeneration'

Table of Contents

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    Book Overview
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    Chapter 1 Generation of Various Telencephalic Regions from Human Embryonic Stem Cells in Three-Dimensional Culture
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    Chapter 2 Generation of a Three-Dimensional Retinal Tissue from Self-Organizing Human ESC Culture
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    Chapter 3 3D Culture for Self-Formation of the Cerebellum from Human Pluripotent Stem Cells Through Induction of the Isthmic Organizer
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    Chapter 4 Reconstitution of a Patterned Neural Tube from Single Mouse Embryonic Stem Cells
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    Chapter 5 Functional Pituitary Tissue Formation
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    Chapter 6 Directed Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Sensory Epithelia in 3D Culture
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    Chapter 7 Generation of Functional Thyroid Tissue Using 3D-Based Culture of Embryonic Stem Cells
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    Chapter 8 Functional Tooth Regeneration
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    Chapter 9 Functional Hair Follicle Regeneration by the Rearrangement of Stem Cells
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    Chapter 10 Functional Salivary Gland Regeneration
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    Chapter 11 Generation of a Bioengineered Lacrimal Gland by Using the Organ Germ Method
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    Chapter 12 Generation of Gastrointestinal Organoids from Human Pluripotent Stem Cells
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    Chapter 13 Generation of a Three-Dimensional Kidney Structure from Pluripotent Stem Cells
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    Chapter 14 Making a Kidney Organoid Using the Directed Differentiation of Human Pluripotent Stem Cells
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    Chapter 15 Liver Regeneration Using Cultured Liver Bud
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    Chapter 16 Formation of Stomach Tissue by Organoid Culture Using Mouse Embryonic Stem Cells
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    Chapter 17 In Vivo Model of Small Intestine
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    Chapter 18 Erratum to: In Vivo Model of Small Intestine
Attention for Chapter 6: Directed Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Sensory Epithelia in 3D Culture
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Chapter title
Directed Differentiation of Mouse Embryonic Stem Cells Into Inner Ear Sensory Epithelia in 3D Culture
Chapter number 6
Book title
Organ Regeneration
Published in
Methods in molecular biology, March 2017
DOI 10.1007/978-1-4939-6949-4_6
Pubmed ID
Book ISBNs
978-1-4939-6947-0, 978-1-4939-6949-4
Authors

Nie, Jing, Koehler, Karl R., Hashino, Eri, Jing Nie, Karl R. Koehler, Eri Hashino

Editors

Takashi Tsuji

Abstract

The inner ear sensory epithelium harbors mechanosensory hair cells responsible for detecting sound and maintaining balance. This protocol describes a three-dimensional (3D) culture system that efficiently generates inner ear sensory epithelia from aggregates of mouse embryonic stem (mES) cells. By mimicking the activations and repressions of key signaling pathways during in vivo inner ear development, mES cell aggregates are sequentially treated with recombinant proteins and small molecule inhibitors for activating or inhibiting the Bmp, TGFβ, Fgf, and Wnt signaling pathways. These stepwise treatments promote mES cells to sequentially differentiate into epithelia representing the non-neural ectoderm, preplacodal ectoderm, otic placodal ectoderm, and ultimately, the hair cell-containing sensory epithelia. The derived hair cells are surrounded by a layer of supporting cells and are innervated by sensory neurons. This in vitro inner ear organoid culture system may serve as a valuable tool in developmental and physiological research, disease modeling, drug testing, and potential cell-based therapies.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 14%
Professor 4 14%
Researcher 4 14%
Student > Master 4 14%
Student > Bachelor 2 7%
Other 4 14%
Unknown 6 21%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 32%
Agricultural and Biological Sciences 5 18%
Neuroscience 2 7%
Medicine and Dentistry 2 7%
Unspecified 1 4%
Other 3 11%
Unknown 6 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 July 2022.
All research outputs
#18,401,176
of 22,792,160 outputs
Outputs from Methods in molecular biology
#7,902
of 13,110 outputs
Outputs of similar age
#234,584
of 308,754 outputs
Outputs of similar age from Methods in molecular biology
#177
of 295 outputs
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So far Altmetric has tracked 13,110 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
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We're also able to compare this research output to 295 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.