Chapter 1 Physiology and Pharmacology of the GABA System: Focus on GABA Receptors

Chapter 2 Development of Subtype-Selective GABAA Receptor Compounds for the Treatment of Anxiety, Sleep Disorders and Epilepsy

Chapter 3 Distribution of GABAA Receptor Subunits in the Human Brain

Chapter 4 Pharmacokinetic Determinants of the Clinical Effects of Benzodiazepine Agonist Hypnotics

Chapter 6 Subcortical Neuromodulation of Feedforward and Feedback Inhibitory Microcircuits by the Reticular Activating System

Chapter 7 Function of GABAB and ρ-Containing GABAA Receptors (GABAC Receptors) in the Regulation of Basic and Higher Integrated Sleep-Waking Processes

Chapter 8 Interactions Between GABAergic and Serotonergic Processes in the Dorsal Raphe Nucleus in the Control of REM Sleep and Wakefulness

Chapter 9 GABA-ergic Modulation of Pontine Cholinergic and Noradrenergic Neurons for REM Sleep Generation

Chapter 10 Involvement of GABAergic Mechanisms in the Laterodorsal and Pedunculopontine Tegmental Nuclei (LDT–PPT) in the Promotion of REM Sleep

Chapter 11 GABAergic Mechanisms in the Ventral Oral Pontine Tegmentum: The REM Sleep-Induction Site – in the Modulation of Sleep–Wake States

Chapter 12 The Role of GABAergic Modulation of Mesopontine Cholinergic Neurotransmission in Rapid Eye Movement (REM) Sleep

Chapter 13 Melatonin and Sleep: Possible Involvement of GABAergic Mechanisms

Chapter 14 GABA Involvement in the Circadian Regulation of Sleep

Chapter 15 Pathophysiology of Sleep Disorders

Chapter 16 Insomnia: Differential Diagnosis and Current Treatment Approach

Chapter 17 Zolpidem in the Treatment of Adult and Elderly Primary Insomnia Patients

Chapter 18 Efficacy and Safety of Zopiclone and Eszopiclone in the Treatment of Primary and Comorbid Insomnia

Chapter 19 Indiplon

Chapter 20 Polysomnographic and Clinical Assessment of Zaleplon for the Treatment of Primary Insomnia