Sigma Receptors: Their Role in Disease and as Therapeutic Targets
Springer International Publishing
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Timeline
Mendeley readers
| Chapter title |
Sigma 1 Receptor and Ion Channel Dynamics in Cancer
|
|---|---|
| Chapter number | 6 |
| Book title |
Sigma Receptors: Their Role in Disease and as Therapeutic Targets
|
| Published in |
Advances in experimental medicine and biology, March 2017
|
| DOI | 10.1007/978-3-319-50174-1_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-950172-7, 978-3-31-950174-1
|
| Authors |
Olivier Soriani, Raphaël Rapetti-Mauss |
| Editors |
Sylvia B. Smith, Tsung-Ping Su |
| Abstract |
SigmaR1 is a multitasking chaperone protein which has mainly been studied in CNS physiological and pathophysiological processes such as pain, memory, neurodegenerative diseases (amyotrophic lateral sclerosis , Parkinson's and Alzheimer's diseases, retinal neurodegeneration ), stroke and addiction . Strikingly, G-protein and ion channels are the main client protein fami lies of this atypical chaperone and the recent advances that have been performed for the last 10 years demonstrate that SigmaR1 is principally activated following tissue injury and disease development to promote cell survival. In this chapter, we synthesize the data enhancing our comprehension of the interaction between SigmaR1 and ion channels and the unexpected consequences of such functional coupling in cancer development. We also describe a model in which the pro-survival functions of SigmaR1 observed in CNS pathologies are hijacked by cancer cells to shape their electrical signature and behavior in response to the tumor microenvironment . |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 20 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Librarian | 2 | 10% |
| Other | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Student > Ph. D. Student | 1 | 5% |
| Student > Master | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 12 | 60% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 3 | 15% |
| Arts and Humanities | 1 | 5% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 5% |
| Psychology | 1 | 5% |
| Agricultural and Biological Sciences | 1 | 5% |
| Other | 2 | 10% |
| Unknown | 11 | 55% |