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Kisspeptin Signaling in Reproductive Biology

Overview of attention for book
Cover of 'Kisspeptin Signaling in Reproductive Biology'

Table of Contents

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    Book Overview
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    Chapter 1 Kisspeptin: Past, Present, and Prologue
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    Chapter 2 Structure, Synthesis, and Phylogeny of Kisspeptin and its Receptor
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    Chapter 3 Neuroanatomy of the Kisspeptin Signaling System in Mammals: Comparative and Developmental Aspects
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    Chapter 4 The Effects of Kisspeptin on Gonadotropin Release in Non-human Mammals
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    Chapter 5 Effects of Kisspeptin on Hormone Secretion in Humans
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    Chapter 6 Kisspeptin excitation of GnRH neurons.
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    Chapter 7 Molecular Biology of the Kisspeptin Receptor: Signaling, Function, and Mutations
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    Chapter 8 Kisspeptin antagonists.
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    Chapter 9 Kisspeptin and Clinical Disorders
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    Chapter 10 Beyond the GnRH Axis: Kisspeptin Regulation of the Oxytocin System in Pregnancy and Lactation
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    Chapter 11 The Development of Kisspeptin Circuits in the Mammalian Brain
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    Chapter 12 Kisspeptin and Puberty in Mammals
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    Chapter 13 Sex Steroid Regulation of Kisspeptin Circuits
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    Chapter 14 Kisspeptin and GnRH pulse generation.
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    Chapter 15 Interactions Between Kisspeptins and Neurokinin B
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    Chapter 16 Electrophysiology of Kisspeptin Neurons
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    Chapter 17 Metabolic Regulation of Kisspeptin
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    Chapter 18 Circadian Regulation of Kisspeptin in Female Reproductive Functioning
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    Chapter 19 Kisspeptin and Seasonality of Reproduction
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    Chapter 20 Stress Regulation of Kisspeptin in the Modulation of Reproductive Function
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    Chapter 21 Effects of Environmental Endocrine Disruptors and Phytoestrogens on the Kisspeptin System
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    Chapter 22 Model systems for studying kisspeptin signalling: mice and cells.
Attention for Chapter 8: Kisspeptin antagonists.
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Chapter title
Kisspeptin antagonists.
Chapter number 8
Book title
Kisspeptin Signaling in Reproductive Biology
Published in
Advances in experimental medicine and biology, April 2013
DOI 10.1007/978-1-4614-6199-9_8
Pubmed ID
23550006
Book ISBNs
978-1-4614-6198-2, 978-1-4614-6199-9
Authors

Roseweir AK, Millar RP, Antonia Kathryn Roseweir, Robert P. Millar, Roseweir, Antonia Kathryn, Millar, Robert P.

Abstract

Kisspeptin is now known to be an important regulator of the hypothalamic--pituitary-gonadal axis and is the target of a range of regulators, such as steroid hormone feedback, nutritional and metabolic regulation. Kisspeptin binds to its cognate receptor, KISS1R (also called GPR54), on GnRH neurons and stimulates their activity, which in turn provides an obligatory signal for GnRH secretion-thus gating down-stream events supporting reproduction. The development of peripherally active kisspeptin antagonists could offer a unique therapeutic agent for treating hormone-dependent disorders of reproduction, including precocious puberty, endometriosis, and metastatic prostate cancer. The following chapter discusses the advances made in the search for both peptide and small molecule kisspeptin antagonists and their use in delineating the role of kisspeptin within the reproductive system. To date, four peptide antagonists and one small molecule antagonist have been designed.

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X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
 Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 36 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 14%
Student > Master 4 11%
Professor 3 8%
Student > Bachelor 3 8%
Student > Doctoral Student 3 8%
Other 8 22%
Unknown 10 28%
Readers by discipline Count As %
Medicine and Dentistry 7 19%
Biochemistry, Genetics and Molecular Biology 4 11%
Agricultural and Biological Sciences 4 11%
Nursing and Health Professions 2 6%
Neuroscience 2 6%
Other 4 11%
Unknown 13 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2013.
All research outputs
#20,200,843
of 22,719,618 outputs
Outputs from Advances in experimental medicine and biology
#3,943
of 4,920 outputs
Outputs of similar age
#174,542
of 199,943 outputs
Outputs of similar age from Advances in experimental medicine and biology
#5
of 7 outputs
Altmetric has tracked 22,719,618 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,920 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 199,943 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 2 of them.

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