| Chapter title |
Oxidative metabolism: glucose versus ketones.
|
|---|---|
| Chapter number | 43 |
| Book title |
Oxygen Transport to Tissue XXXV
|
| Published in |
Advances in experimental medicine and biology, July 2013
|
| DOI | 10.1007/978-1-4614-7411-1_43 |
| Pubmed ID | |
| Book ISBNs |
978-1-4614-7256-8, 978-1-4614-7411-1
|
| Authors |
Prince A, Zhang Y, Croniger C, Puchowicz M, Allison Prince, Yifan Zhang, Colleen Croniger, Michelle Puchowicz, Prince, Allison, Zhang, Yifan, Croniger, Colleen, Puchowicz, Michelle |
| Editors |
Sabine Van Huffel, Gunnar Naulaers, Alexander Caicedo, Duane F. Bruley, David K. Harrison |
| Abstract |
The coupling of upstream oxidative processes (glycolysis, beta-oxidation, CAC turnover) to mitochondrial oxidative phosphorylation (OXPHOS) under the driving conditions of energy demand by the cell results in the liberation of free energy as ATP. Perturbations in glycolytic CAC or OXPHOS can result in pathology or cell death. To better understand whole body energy expenditure during chronic ketosis, we used a diet-induced rat model of ketosis to determine if high-fat-carbohydrate-restricted "ketogenic" diet results in changes in total energy expenditure (TEE). Consistent with previous reports of increased energy expenditure in mice, we hypothesized that rats fed ketogenic diet for 3 weeks would result in increased resting energy expenditure due to alterations in metabolism associated with a "switch" in energy substrate from glucose to ketone bodies. The rationale is ketone bodies are a more efficient fuel than glucose. Indirect calorimetric analysis revealed a moderate increase in VO2 and decreased VCO2 and heat with ketosis. These results suggest ketosis induces a moderate uncoupling state and less oxidative efficiency compared to glucose oxidation. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 30% |
| Germany | 1 | 10% |
| India | 1 | 10% |
| Brazil | 1 | 10% |
| Unknown | 4 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 70% |
| Practitioners (doctors, other healthcare professionals) | 2 | 20% |
| Scientists | 1 | 10% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 25% |
| Researcher | 11 | 21% |
| Student > Ph. D. Student | 6 | 12% |
| Other | 4 | 8% |
| Student > Master | 4 | 8% |
| Other | 3 | 6% |
| Unknown | 11 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 8 | 15% |
| Biochemistry, Genetics and Molecular Biology | 6 | 12% |
| Agricultural and Biological Sciences | 6 | 12% |
| Neuroscience | 6 | 12% |
| Psychology | 3 | 6% |
| Other | 9 | 17% |
| Unknown | 14 | 27% |