Biomedical Nanotechnology
Springer New York
Chapter title |
Glucose-Responsive Insulin Delivery by Microneedle-Array Patches Loaded with Hypoxia-Sensitive Vesicles
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Chapter number | 17 |
Book title |
Biomedical Nanotechnology
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Published in |
Methods in molecular biology, February 2017
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DOI | 10.1007/978-1-4939-6840-4_17 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6838-1, 978-1-4939-6840-4
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Authors |
Jicheng Yu, Yuqi Zhang, Zhen Gu |
Editors |
Sarah Hurst Petrosko, Emily S. Day |
Abstract |
In this chapter, we describe the preparation of glucose-responsive vesicles (GRVs) and the fabrication of GRV-loaded microneedle-array patches for insulin delivery. The GRVs were formed of hypoxia-sensitive hyaluronic acid (HS-HA), the synthesis of which is presented in detail. We also describe the procedure to evaluate the in vivo efficacy of this smart patch in a mouse model of chemically induced type 1 diabetes through transcutaneous administration. |
Country | Count | As % |
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Unknown | 15 | 100% |
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 2 | 13% |
Student > Bachelor | 2 | 13% |
Unspecified | 1 | 7% |
Other | 1 | 7% |
Researcher | 1 | 7% |
Other | 1 | 7% |
Unknown | 7 | 47% |
Readers by discipline | Count | As % |
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Pharmacology, Toxicology and Pharmaceutical Science | 5 | 33% |
Engineering | 2 | 13% |
Medicine and Dentistry | 1 | 7% |
Unspecified | 1 | 7% |
Unknown | 6 | 40% |