Chapter title |
Spectroscopic Photoacoustic Imaging of Gold Nanorods
|
---|---|
Chapter number | 12 |
Book title |
Biomedical Nanotechnology
|
Published in |
Methods in molecular biology, February 2017
|
DOI | 10.1007/978-1-4939-6840-4_12 |
Pubmed ID | |
Book ISBNs |
978-1-4939-6838-1, 978-1-4939-6840-4
|
Authors |
Austin Van Namen, Geoffrey P. Luke |
Editors |
Sarah Hurst Petrosko, Emily S. Day |
Abstract |
Photoacoustic imaging is a rapidly developing tool capable of achieving high-resolution images with optical contrast at imaging depths up to a few centimeters. When combined with targeted nanoparticle contrast agents, sensitive detection of molecular signatures is possible. In this chapter, we discuss the achievements and future directions of nanoparticle-augmented photoacoustic imaging. We present a method to synthesize silica-coated gold nanorods, which are highly stable, signal amplifying photoacoustic contrast agents, and also describe spectroscopic image acquisition and processing steps to provide a specific map of nanoparticle distribution in vivo. |
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