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Genotoxicity Assessment

Overview of attention for book
Cover of 'Genotoxicity Assessment'

Table of Contents

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    Book Overview
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    Chapter 1 Bacterial Mutation Assays
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    Chapter 2 In Vitro Mouse Lymphoma (L5178Y Tk +/− -3.7.2C) Forward Mutation Assay
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    Chapter 3 Erythrocyte-Based Pig-a Gene Mutation Assay
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    Chapter 4 Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes
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    Chapter 5 In Vivo cII , gpt , and Spi − Gene Mutation Assays in Transgenic Mice and Rats
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    Chapter 6 In Vitro Cytogenetic Assays: Chromosomal Aberrations and Micronucleus Tests
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    Chapter 7 Analysis of Chromosome Aberrations in Somatic and Germ Cells of the Mouse
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    Chapter 8 Chromosomal aberration test in human lymphocytes.
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    Chapter 9 In Vivo Micronucleus Assay in Mouse Bone Marrow and Peripheral Blood
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    Chapter 10 Micronucleus Assay in Human Cells: Lymphocytes and Buccal Cells
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    Chapter 11 Flow Cytometric Determination of Micronucleus Frequency
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    Chapter 12 Fluorescence In Situ Hybridization (FISH) Technique for the Micronucleus Test
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    Chapter 13 Comparative Genomic Hybridization (CGH) in Genotoxicology
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    Chapter 14 The In Vitro Micronucleus Assay and Kinetochore Staining: Methodology and Criteria for the Accurate Assessment of Genotoxicity and Cytotoxicity
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    Chapter 15 γ-H2AX Detection in Somatic and Germ Cells of Mice
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    Chapter 16 Multicolor Laser Scanning Confocal Immunofluorescence Microscopy of DNA Damage Response Biomarkers
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    Chapter 17 The Comet Assay: Assessment of In Vitro and In Vivo DNA Damage
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    Chapter 18 The Comet Assay in Human Biomonitoring
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    Chapter 19 The Comet Assay in Marine Animals
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    Chapter 20 Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells In Vivo
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    Chapter 21 32 P-Postlabeling Analysis of DNA Adducts
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    Chapter 22 Micronucleus Assay with Tetrad Cells of Tradescantia
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    Chapter 23 The wing-spot and the comet tests as useful assays detecting genotoxicity in Drosophila.
  25. Altmetric Badge
    Chapter 24 Genotoxicity Guidelines Recommended by International Conference of Harmonization (ICH)
Attention for Chapter 23: The wing-spot and the comet tests as useful assays detecting genotoxicity in Drosophila.
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Chapter title
The wing-spot and the comet tests as useful assays detecting genotoxicity in Drosophila.
Chapter number 23
Book title
Genotoxicity Assessment
Published in
Methods in molecular biology, January 2013
DOI 10.1007/978-1-62703-529-3_23
Pubmed ID
Book ISBNs
978-1-62703-528-6, 978-1-62703-529-3
Authors

Ricard Marcos, Erico R. Carmona

Abstract

In spite of its pioneer use in detecting mutational processes, Drosophila has yet an important role in studies aiming to detect and quantify the induction of DNA damage. Here we describe two assays, one detecting primary damage (the Comet assay) and the other detecting somatic mutation and recombination effects (wing-spot test). It is important to emphasize that somatic recombination is a key event in cancer and no assays exist to detect and quantify somatic recombination processes, other than the spot tests developed in Drosophila.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 10 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 10 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 2 20%
Student > Ph. D. Student 2 20%
Researcher 2 20%
Professor 1 10%
Professor > Associate Professor 1 10%
Other 0 0%
Unknown 2 20%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 2 20%
Agricultural and Biological Sciences 2 20%
Environmental Science 1 10%
Chemical Engineering 1 10%
Engineering 1 10%
Other 0 0%
Unknown 3 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2014.
All research outputs
#15,866,607
of 23,577,654 outputs
Outputs from Methods in molecular biology
#5,555
of 13,410 outputs
Outputs of similar age
#185,695
of 284,930 outputs
Outputs of similar age from Methods in molecular biology
#176
of 335 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 13,410 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
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We're also able to compare this research output to 335 others from the same source and published within six weeks on either side of this one. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.