Report for: Death Receptors and Cognate Ligands in Cancer

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Chapter title	The role of TNF in cancer.
Chapter number	26
Book title	Death Receptors and Cognate Ligands in Cancer
Published in	Results and problems in cell differentiation, January 2009
DOI	10.1007/400_2008_26
Pubmed ID	19137269
Book ISBNs	978-3-64-203044-4, 978-3-64-203045-1
Authors	Wajant H, Harald Wajant
Abstract	Tumor necrosis factor (TNF) is an extraordinarily pleiotropic cytokine with a central role in immune homeostasis, inflammation, and host defense. Dependent on the cellular context, it can induce such diverse effects as apoptosis, necrosis, angiogenesis, immune cell activation, differentiation, and cell migration. These processes are of great relevance in tumor immune surveillance, and also play crucial roles in tumor development and tumor progression. It is therefore no surprise that TNF in a context-dependent manner displays pro- and antitumoral effects. Modulation of the activity of the TNF-TNF receptor system thus offers manifold possibilities for cancer therapy. In fact, TNF in combination with melphalan is already an established treatment option in the therapy of advanced soft tissue sarcoma of the extremities and many preclinical data suggest that TNF neutralization could also be exploited to fight cancer or cancer-associated complications.

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Mendeley readers

The data shown below were compiled from readership statistics for 98 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Lebanon	1	1%
Germany	1	1%
Unknown	96	98%

Demographic breakdown

Readers by professional status	Count	As %
Student > Bachelor	18	18%
Student > Ph. D. Student	17	17%
Student > Master	16	16%
Researcher	9	9%
Student > Doctoral Student	7	7%
Other	10	10%
Unknown	21	21%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	19	19%
Agricultural and Biological Sciences	19	19%
Medicine and Dentistry	13	13%
Immunology and Microbiology	8	8%
Chemistry	3	3%
Other	13	13%
Unknown	23	23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 June 2013.

All research outputs

#20,196,270

of 22,714,025 outputs

Outputs from Results and problems in cell differentiation

#163

of 217 outputs

Outputs of similar age

#164,183

of 169,895 outputs

Outputs of similar age from Results and problems in cell differentiation

of 5 outputs

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So far Altmetric has tracked 217 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.

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Death Receptors and Cognate Ligands in Cancer

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Geographical breakdown

Demographic breakdown

Attention Score in Context