| Chapter title |
Strategies Involving Mass Spectrometry Combined with Capillary Electrophoresis in Metabolomics
|
|---|---|
| Chapter number | 5 |
| Book title |
Metabolomics: From Fundamentals to Clinical Applications
|
| Published in |
Advances in experimental medicine and biology, January 2017
|
| DOI | 10.1007/978-3-319-47656-8_5 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-947655-1, 978-3-31-947656-8
|
| Authors |
Karina Trevisan Rodrigues, Zuzana Cieslarová, Marina Franco Maggi Tavares, Ana Valéria Colnaghi Simionato |
| Editors |
Alessandra Sussulini |
| Abstract |
This chapter focuses on the important contribution of CE-MS in metabolomics, describing the nature of CE-MS coupling and the technical improvements that have led to the interfaces used in modern instrumentation. Moreover, it will discourse how the variety of electrolyte compositions and additives, which has conferred CE the exceptional selectivity of its multiple separation modes, has been handled to allow interfacing with MS without compromising ionization efficiency and the spectrometer integrity. Finally, the methodologies of CE-MS in current use for metabolomics will be discussed in detail. To verify the scope of CE-MS in clinical metabolomics, a myriad of representative applications has been compiled. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Doctoral Student | 6 | 21% |
| Student > Ph. D. Student | 6 | 21% |
| Student > Master | 5 | 17% |
| Researcher | 4 | 14% |
| Other | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 4 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 21% |
| Chemistry | 6 | 21% |
| Medicine and Dentistry | 3 | 10% |
| Neuroscience | 2 | 7% |
| Immunology and Microbiology | 1 | 3% |
| Other | 5 | 17% |
| Unknown | 6 | 21% |