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Clinical Applications of Mass Spectrometry

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Cover of 'Clinical Applications of Mass Spectrometry'

Table of Contents

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    Book Overview
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    Chapter 1 The Evolution of Mass Spectrometry in the Clinical Laboratory
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    Chapter 2 Measurement of Plasma/Serum Acylcarnitines Using Tandem Mass Spectrometry
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    Chapter 3 Comprehensive Determination of Amino Acids for Diagnosis of Inborn Errors of Metabolism
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    Chapter 4 Identification and Quantitation of Amphetamine, Methamphetamine, MDMA, Pseudoephedrine, and Ephedrine in Blood, Plasma, and Serum Using Gas Chromatography-Mass Spectrometry (GC/MS)
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    Chapter 5 Quantification of Antidepressants Using Gas Chromatography-Mass Spectrometry
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    Chapter 6 Quantitation of Argatroban in Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (UPLC-ESI-MS/MS)
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    Chapter 7 Quantitation of Amobarbital, Butalbital, Pentobarbital, Phenobarbital, and Secobarbital in Urine, Serum, and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 8 Quantitation of Benzodiazepines in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 9 LC-MS/MS Analysis of 13 Benzodiazepines and Metabolites in Urine, Serum, Plasma, and Meconium
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    Chapter 10 Simultaneous Determination and Quantification of 12 Benzodiazepines in Serum or Whole Blood Using UPLC/MS/MS
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    Chapter 11 Determination of Benzoic Acid in Serum or Plasma by Gas Chromatography-Mass Spectrometry (GC/MS)
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    Chapter 12 Quantification of Busulfan in Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS)
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    Chapter 13 Quantitation of Total 11-Nor-9-Carboxy-Delta 9-Tetrahydrocannabinol in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 14 Quantitation of Cocaine, Benzoylecgonine, Ecgonine Methyl Ester, and Cocaethylene in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 15 Identification and Quantitation of Cocaine, Benzoylecgonine, and Cocaethylene in Blood, Serum, and Plasma Using Ultra-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry (UPLC-MS/MS)
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    Chapter 16 Detection and Quantification of Cocaine and Benzoylecgonine in Meconium Using Solid Phase Extraction and UPLC/MS/MS
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    Chapter 17 Diagnosis of Creatine Metabolism Disorders by Determining Creatine and Guanidinoacetate in Plasma and Urine
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    Chapter 18 Broad Spectrum Drug Screening Using Electron-Ionization Gas Chromatography-Mass Spectrometry (EI-GCMS)
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    Chapter 19 Broad Spectrum Drug Screening Using Liquid Chromatography-Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometry
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    Chapter 20 High Sensitivity Measurement of Estrone and Estradiol in Serum and Plasma Using LC-MS/MS
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    Chapter 21 3-Hydroxy-Fatty Acid Analysis by Gas Chromatography-Mass Spectrometry
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    Chapter 22 Quantitation of Fentanyl in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 23 Determination of Total Homocysteine in Plasma Using Liquid Chromatography Coupled to Tandem Mass Spectrometry (LC/MS/MS)
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    Chapter 24 Quantitation of Homovanillic Acid (HVA) and Vanillylmandelic Acid (VMA) in Urine Using Gas Chromatography-Mass Spectrometry (GC/MS)
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    Chapter 25 Quantitation of 17-OH-Progesterone (OHPG) for Diagnosis of Congenital Adrenal Hyperplasia (CAH)
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    Chapter 26 Determination of Hydroxyurea in Serum or Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 27 Quantitation of Ibuprofen in Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 28 Quantitation of Indomethacin in Serum and Plasma Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 29 Quantitation of Iothalamate in Urine and Plasma Using Liquid Chromatography Electrospray Tandem Mass Spectrometry (HPLC-ESI-MS/MS)
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    Chapter 30 Identification and Quantitation of Ketamine in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 31 Measurement of Filter Paper Bloodspot Lead by Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)
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    Chapter 32 Multiplex Lysosomal Enzyme Activity Assay on Dried Blood Spots Using Tandem Mass Spectrometry
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    Chapter 33 Gas Chromatography-Mass Spectrometry Method for the Determination of Methadone and 2-Ethylidene-1,5-Dimethyl-3, 3-Diphenylpyrrolidine (EDDP)
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    Chapter 34 Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS) Method for Monitoring Methotrexate in the Setting of Carboxypeptidase-G2 Therapy
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    Chapter 35 Quantitation of Methylmalonic Acid in Serum or Plasma Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry
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    Chapter 36 Quantitation of Methylmalonic Acid in Plasma Using Liquid Chromatography – Tandem Mass Spectrometry
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    Chapter 37 Monitoring of Mycophenolate Acid in Serum or Plasma Using LC Tandem Mass Spectrometry
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    Chapter 38 Quantitation of Nicotine, Its Metabolites, and Other Related Alkaloids in Urine, Serum, and Plasma Using LC-MS-MS
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    Chapter 39 Quantitation of Opioids in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 40 Quantitation of Morphine, Codeine, Hydrocodone, Hydromorphone, Oxycodone, Oxymorphone, and 6-Monoacetylmorphine (6-MAM) in Urine, Blood, Serum, or Plasma Using Liquid Chromatography with Tandem Mass Spectrometry Detection
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    Chapter 41 Urine organic acid analysis for inherited metabolic disease using gas chromatography-mass spectrometry.
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    Chapter 42 Identification of Urine Organic Acids for the Detection of Inborn Errors of Metabolism Using Urease and Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 43 Quantitation of Orotic Acid in Urine Using Isotope Dilution-Selected Ion Gas Chromatography-Mass Spectrometry
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    Chapter 44 Quantitation of Oxycodone in Blood and Urine Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 45 Quantitation of Phencyclidine (PCP) in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 46 Quantitation of Sirolimus Using Liquid Chromatography-Tandem Mass Spectrometry (LC-MS-MS)
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    Chapter 47 Quantitation of Tacrolimus in Whole Blood Using High Performance Liquid Chromatography-Tandem Mass Spectrometry (HPLC-MS-MS)
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    Chapter 48 Analysis of Testosterone in Serum Using Mass Spectrometry
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    Chapter 49 Determination of Tetrahydrozoline in Urine and Blood Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 50 Quantitation of 25-OH-vitamin D (25OHD) using liquid tandem mass spectrometry (LC-MS-MS).
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    Chapter 51 Identification and Quantitation of Zolpidem in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS)
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    Chapter 52 Identification and Quantitation of Zopiclone in Biological Matrices Using Gas Chromatography-Mass Spectrometry (GC-MS)
Attention for Chapter 50: Quantitation of 25-OH-vitamin D (25OHD) using liquid tandem mass spectrometry (LC-MS-MS).
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

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Chapter title
Quantitation of 25-OH-vitamin D (25OHD) using liquid tandem mass spectrometry (LC-MS-MS).
Chapter number 50
Book title
Clinical Applications of Mass Spectrometry
Published in
Methods in molecular biology, December 2009
DOI 10.1007/978-1-60761-459-3_50
Pubmed ID
Book ISBNs
978-1-60761-458-6, 978-1-60761-459-3
Authors

Singh RJ, Ravinder J. Singh, Singh, Ravinder J.

Abstract

25-OH-vitamin D (25OHD) is ordered and interpreted clinically in light of calcium balance and homeostasis. Various methodologies including immunoassay and chromatography are described for the measurement of 25OHD in biological fluids. It is well reported that all existing methods are challenging and require a high level of technical expertise. While this is also true of the methods using liquid chromatography-tandem mass spectrometry (LC-MS-MS), the technique is gaining favor in various laboratories because it offers advantages of greatly improved specificity and sensitivity.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 13 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 8%
Switzerland 1 8%
Unknown 11 85%

Demographic breakdown

Readers by professional status Count As %
Researcher 3 23%
Student > Ph. D. Student 2 15%
Other 1 8%
Student > Doctoral Student 1 8%
Professor 1 8%
Other 3 23%
Unknown 2 15%
Readers by discipline Count As %
Medicine and Dentistry 4 31%
Agricultural and Biological Sciences 2 15%
Chemistry 2 15%
Immunology and Microbiology 1 8%
Biochemistry, Genetics and Molecular Biology 1 8%
Other 0 0%
Unknown 3 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 May 2015.
All research outputs
#3,705,927
of 22,712,476 outputs
Outputs from Methods in molecular biology
#927
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Outputs of similar age
#21,277
of 163,220 outputs
Outputs of similar age from Methods in molecular biology
#12
of 120 outputs
Altmetric has tracked 22,712,476 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 13,079 research outputs from this source. They receive a mean Attention Score of 3.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 163,220 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 120 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.