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Dendritic Spines

Overview of attention for book
Dendritic Spines
Springer International Publishing
Attention for Chapter: Morphological Features of Human Dendritic Spines.
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Chapter title
Morphological Features of Human Dendritic Spines.
Book title
Dendritic Spines
Published in
Advances in neurobiology, November 2023
DOI 10.1007/978-3-031-36159-3_9
Pubmed ID
Book ISBNs
978-3-03-136158-6, 978-3-03-136159-3
Authors

Renner, Josué, Rasia-Filho, Alberto A, Rasia-Filho, Alberto A., Josué Renner, Alberto A. Rasia-Filho

Abstract

Dendritic spine features in human neurons follow the up-to-date knowledge presented in the previous chapters of this book. Human dendrites are notable for their heterogeneity in branching patterns and spatial distribution. These data relate to circuits and specialized functions. Spines enhance neuronal connectivity, modulate and integrate synaptic inputs, and provide additional plastic functions to microcircuits and large-scale networks. Spines present a continuum of shapes and sizes, whose number and distribution along the dendritic length are diverse in neurons and different areas. Indeed, human neurons vary from aspiny or "relatively aspiny" cells to neurons covered with a high density of intermingled pleomorphic spines on very long dendrites. In this chapter, we discuss the phylogenetic and ontogenetic development of human spines and describe the heterogeneous features of human spiny neurons along the spinal cord, brainstem, cerebellum, thalamus, basal ganglia, amygdala, hippocampal regions, and neocortical areas. Three-dimensional reconstructions of Golgi-impregnated dendritic spines and data from fluorescence microscopy are reviewed with ultrastructural findings to address the complex possibilities for synaptic processing and integration in humans. Pathological changes are also presented, for example, in Alzheimer's disease and schizophrenia. Basic morphological data can be linked to current techniques, and perspectives in this research field include the characterization of spines in human neurons with specific transcriptome features, molecular classification of cellular diversity, and electrophysiological identification of coexisting subpopulations of cells. These data would enlighten how cellular attributes determine neuron type-specific connectivity and brain wiring for our diverse aptitudes and behavior.

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The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 7 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 57%
Student > Postgraduate 1 14%
Unknown 2 29%
Readers by discipline Count As %
Neuroscience 3 43%
Psychology 1 14%
Biochemistry, Genetics and Molecular Biology 1 14%
Unknown 2 29%