Chapter title |
Muscarinic receptor antagonists: effects on pulmonary function.
|
---|---|
Chapter number | 14 |
Book title |
Muscarinic Receptors
|
Published in |
Handbook of experimental pharmacology, November 2011
|
DOI | 10.1007/978-3-642-23274-9_14 |
Pubmed ID | |
Book ISBNs |
978-3-64-223273-2, 978-3-64-223274-9
|
Authors |
Buels KS, Fryer AD, Kalmia S. Buels, Allison D. Fryer, Arthur Christopoulos, Neil M. Nathanson, Buels, Kalmia S., Fryer, Allison D. |
Editors |
Allison D. Fryer, Arthur Christopoulos, Neil M. Nathanson |
Abstract |
In healthy lungs, muscarinic receptors control smooth muscle tone, mucus secretion, vasodilation, and inflammation. In chronic obstructive pulmonary disease (COPD) and asthma, cholinergic mechanisms contribute to increased bronchoconstriction and mucus secretion that limit airflow. This chapter reviews neuronal and nonneuronal sources of acetylcholine in the lung and the expression and role of M₁, M₂, and M₃ muscarinic receptor subtypes in lung physiology. It also discusses the evidence for and against the role of parasympathetic nerves in asthma, and the current use and therapeutic potential of muscarinic receptor antagonists in COPD and asthma. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 234 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 53 | 23% |
Student > Master | 20 | 9% |
Researcher | 17 | 7% |
Student > Ph. D. Student | 16 | 7% |
Other | 14 | 6% |
Other | 25 | 11% |
Unknown | 89 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 38 | 16% |
Medicine and Dentistry | 31 | 13% |
Biochemistry, Genetics and Molecular Biology | 20 | 9% |
Agricultural and Biological Sciences | 18 | 8% |
Chemistry | 8 | 3% |
Other | 31 | 13% |
Unknown | 88 | 38% |