Chaperones
Springer US
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| Chapter title |
Monitoring of the Heat Shock Response with a Real-Time Luciferase Reporter.
|
|---|---|
| Book title |
Chaperones
|
| Published in |
Methods in molecular biology, January 2023
|
| DOI | 10.1007/978-1-0716-3342-7_1 |
| Pubmed ID | |
| Book ISBNs |
978-1-07-163341-0, 978-1-07-163342-7
|
| Authors |
Ackerman, Andrew, Kijima, Toshiki, Eguchi, Takanori, Prince, Thomas L, Prince, Thomas L. |
| Abstract |
The heat shock response (HSR) is a cellular mechanism for counteracting acute proteotoxic stress. In eukaryotes, transcriptional activation of the HSR is regulated by heat shock factor 1 (HSF1). Activation of HSF1 induces the expression of heat shock proteins (HSPs) that function as molecular chaperones to fold and maintain the three-dimensional structure of misfolded proteins. The regulation of the degree and duration of the HSR is controlled by multiple biochemical mechanisms that include posttranslational modification of HSF1 and numerous protein-protein interactions. In this chapter, we describe a method to evaluate the activation and deactivation of the HSR at the transcriptional level using a short half-life luciferase reporter assay. This assay can be used to further characterize the HSR or as a screen for small molecule inducers, amplifiers, or repressors. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 1 Mendeley reader of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Unspecified | 1 | 100% |
| Readers by discipline | Count | As % |
|---|---|---|
| Unspecified | 1 | 100% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 August 2023.
All research outputs
#16,438,713
of 24,212,485 outputs
Outputs from Methods in molecular biology
#5,693
of 13,627 outputs
Outputs of similar age
#249,653
of 445,489 outputs
Outputs of similar age from Methods in molecular biology
#257
of 639 outputs
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So far Altmetric has tracked 13,627 research outputs from this source. They receive a mean Attention Score of 3.5. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
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